التفاصيل البيبلوغرافية
| العنوان: |
Promising therapy candidates for liver fibrosis |
| المؤلفون: |
Wang, Ping, Koyama, Yukinori, Liu, Xiao, Xu, Jun, Ma, Hsiao Yen, Liang, Shuang, Kim, In H., Brenner, David A., Kisseleva, Tatiana |
| المساهمون: |
小山, 幸法, 90450238 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2016 |
| المجموعة: |
Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| مصطلحات موضوعية: |
liver fibrosis, hepatocytes, cholangiocyte, inflammation, myofibroblasts, early-phase clinical trial |
| الوصف: |
Liver fibrosis is a wound-healing process in response to repeated and chronic injury to hepatocytes and/or cholangiocytes. Ongoing hepatocyte apoptosis or necrosis lead to increase in ROS production and decrease in antioxidant activity, which recruits inflammatory cells from the blood and activate hepatic stellate cells (HSCs) changing to myofibroblasts. Injury to cholangiocytes also recruits inflammatory cells to the liver and activates portal fibroblasts in the portal area, which release molecules to activate and amplify cholangiocytes. No matter what origin of myofibroblasts, either HSCs or portal fibroblasts, they share similar characteristics, including being positive for a-smooth muscle actin and producing extracellular matrix. Based on the extensive pathogenesis knowledge of liver fibrosis, therapeutic strategies have been designed to target each step of this process, including hepatocyte apoptosis, cholangiocyte proliferation, inflammation, and activation of myofibroblasts to deposit extracellular matrix, yet the current therapies are still in early-phase clinical development. There is an urgent need to translate the molecular mechanism of liver fibrosis to effective and potent reagents or therapies in human. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
1664-042X |
| العلاقة: |
http://hdl.handle.net/2433/214318Test; Frontiers in Physiology; 47 |
| الإتاحة: |
http://hdl.handle.net/2433/214318Test |
| حقوق: |
© 2016 Wang, Koyama, Liu, Xu, Ma, Liang, Kim, Brenner and Kisseleva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| رقم الانضمام: |
edsbas.218C9678 |
| قاعدة البيانات: |
BASE |
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