دورية أكاديمية
ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization
| العنوان: | ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization |
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| المؤلفون: | Hino, Naoya, Rossetti, Leone, Marín-Llauradó, Ariadna, Aoki, Kazuhiro, Trepat, Xavier, Matsuda, Michiyuki, Hirashima, Tsuyoshi |
| المساهمون: | 日野, 直也, 青木, 一洋, 松田, 道行, 平島, 剛志, 80881531, 10620198 |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2020 |
| المجموعة: | Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ |
| مصطلحات موضوعية: | collective cell migration, ERK/MAPK, EGFR, FRET, front-rear polarity, intercellular signal transfer, mathematical model, mechanochemical feedback, mechanotransduction, wave propagation |
| الوصف: | 分子活性の波が細胞集団に伝わる制御機構を解明 --細胞同士の綱引きが情報を遠くに伝える--. 京都大学プレスリリース. 2020-06-04. ; Cells communicate by doing the 'wave'. 京都大学プレスリリース. 2020-07-22. ; During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale expanse. Although the collective cell migration is known to be directed by mechanical forces transmitted via cell-cell junctions, it remains elusive how the intercellular force transmission is coordinated with intracellular biochemical signaling to achieve collective movements. Here, we show that intercellular coupling of extracellular signal-regulated kinase (ERK)-mediated mechanochemical feedback yields long-distance transmission of guidance cues. Mechanical stretch activates ERK through epidermal growth factor receptor (EGFR) activation, and ERK activation triggers cell contraction. The contraction of the activated cell pulls neighboring cells, evoking another round of ERK activation and contraction in the neighbors. Furthermore, anisotropic contraction based on front-rear polarization guarantees unidirectional propagation of ERK activation, and in turn, the ERK activation waves direct multicellular alignment of the polarity, leading to long-range ordered migration. Our findings reveal that mechanical forces mediate intercellular signaling underlying sustained transmission of guidance cues for collective cell migration. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1534-5807 1878-1551 |
| العلاقة: | https://www.kyoto-u.ac.jp/ja/research-news/2020-06-04Test; http://hdl.handle.net/2433/253559Test; Developmental Cell; 53; 646; 660.e8 |
| الإتاحة: | http://hdl.handle.net/2433/253559Test |
| حقوق: | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; The full-text file will be made open to the public on 22 JUNE 2021 in accordance with publisher's 'Terms and Conditions for Self-Archiving' ; This is not the published version. Please cite only the published version. ; この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
| رقم الانضمام: | edsbas.5E3D8121 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15345807 18781551 |
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