دورية أكاديمية
Histopathological and biomechanical investigation of the effect of momordica charantia on fracture healing, kidney, and liver: An experimental rat model
| العنوان: | Histopathological and biomechanical investigation of the effect of momordica charantia on fracture healing, kidney, and liver: An experimental rat model |
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| المؤلفون: | Öztürk, Burhan, İnal, Sermet, Dülgeroğlu, T. Cihan, Üzümcügil, A. Oktar, Değer, Ayşenur, Kuyubaşı, S. Numan, Karayel, H. Basri, Gök, Kadir |
| المساهمون: | İnal, Sermet |
| بيانات النشر: | World Scientific |
| سنة النشر: | 2021 |
| المجموعة: | Kütahya Dumlupınar University Institutional Repository |
| مصطلحات موضوعية: | Fracture Healing, Kidney, Liver, Momordica Charantia, Rat |
| الوصف: | Momordica charantia (MC) is a plant belonging to the family Cucurbitaceae. MC has antidiabetic, antibacterial, antioxidant, antimutagenic, antiulcerative, antiinflammatory and antilipidemic effects. However, information on the effect of MC on fracture union is lacking. This study aimed to examine the effect of MC on fracture union histopathologically and biomechanically. A total of 42 male Wistar-Albino rats were randomly divided into 3 groups, 14 in each group. A diaphyseal fracture was created on the right tibia of all rats. All fractures were fixed with a Kirschner (K) wire. The rats in Group I did not undergo any further procedures (Control group). Group II rats were treated with 0.9% saline oral gavage at a dose of 500μL/day for 28 days [Saline (S) group]. The rats in Group III were given 300mg/kg MC extract per day, dissolved in 500μL 0.9% saline by oral gavage for 28 days [MC (Extract) group]. After 28 days, all rats were sacrificed. Each group was randomly divided into two subgroups. The histopathological examination was performed on the right tibia of rats in the first subgroup and the biomechanical examination in the second subgroup. The kidneys and livers of all rats were evaluated histopathologically. Fracture union was significantly better in the Extract group compared with the Control and S groups histopathologically. The fracture inflammation values were lower in the Extract group than in the other groups. No statistically significant difference was found between the groups in terms of possible side effects to kidneys and livers. In terms of biomechanics, fracture union was significantly better in the Extract group compared with the Control and S groups except yield displacement values. MC had a positive effect on fracture union histopathologically and biomechanically. © 2021 World Scientific Publishing Company. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Journal of Mechanics in Medicine and Biology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Scopus; https://hdl.handle.net/20.500.12438/9233Test |
| الإتاحة: | https://doi.org/20.500.12438/9233Test https://hdl.handle.net/20.500.12438/9233Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.6D01FD4D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |