المؤلفون: Kortunay, Selim, Erken, Haydar Ali, Erken, Gülten, Genç, Osman, Şahiner, Melike, Turgut, Sebahat, Turgut, Günfer

مصطلحات موضوعية: EEG, Epilepsy, Orexin, Penicillin, Power spectrum, Seizure

الوصف: Orexins have been implicated with physiological function including sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on excitability are controversial. We investigated the effects of intracortical injections of orexin A (100 pmol) and B (100 pmol) on the electrophysiological manifestation of epileptic seizures induced by cortical penicillin application in adult male rats. In comparison to saline, orexin A and B enhanced significantly the spike number, spike amplitude and spectral power values induced by cortical penicillin. Our findings indicates that orexins enhances the hyperexcitable and hypersyncronic cortical epileptic activity induced by focal application of penicillin-G. © 2012 Elsevier Inc. All rights reserved. ; 2003SBE001 ; This study was supported by Pamukkale University Research Fund ( 2003SBE001 ).

العلاقة: Peptides; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1016/j.peptides.2012.02.013Test; https://hdl.handle.net/20.500.12438/5209Test; 34; 419; 422

الإتاحة: https://doi.org/20.500.12438/5209Test
https://doi.org/10.1016/j.peptides.2012.02.013Test
https://hdl.handle.net/20.500.12438/5209Test

المؤلفون: Erken, Haydar Ali, Erken, Gülten, Gen, Osman, Kortunay, Selim, Ahiner, Melike, Turgut, Günfer, Turgut, Sebahat

مصطلحات موضوعية: EEG, Epilepsy, Hypocretin, Orexin, Power spectrum, Seizure

الوصف: Orexins have been implicated in the regulation of sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on epileptic activity are controversial. We investigated whether intracortical injections of orexin A (100 pmol) and B (100 pmol) cause epileptic activity in rats. We observed epileptic seizure findings on these two groups rats. Orexin A and B also significantly increased total EEG power spectrum. Our findings indicate that orexins cause epileptic activity. © 2012 Elsevier Inc. ; This study was supported by Pamukkale University Research Fund .

العلاقة: Peptides; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1016/j.peptides.2012.06.012Test; https://hdl.handle.net/20.500.12438/5154Test; 37; 161; 164

الإتاحة: https://doi.org/20.500.12438/5154Test
https://doi.org/10.1016/j.peptides.2012.06.012Test
https://hdl.handle.net/20.500.12438/5154Test