دورية أكاديمية
Orexins increase penicillin-induced epileptic activity
| العنوان: | Orexins increase penicillin-induced epileptic activity |
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| المؤلفون: | Kortunay, Selim, Erken, Haydar Ali, Erken, Gülten, Genç, Osman, Şahiner, Melike, Turgut, Sebahat, Turgut, Günfer |
| سنة النشر: | 2012 |
| المجموعة: | Kütahya Dumlupınar University Institutional Repository |
| مصطلحات موضوعية: | EEG, Epilepsy, Orexin, Penicillin, Power spectrum, Seizure |
| الوصف: | Orexins have been implicated with physiological function including sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on excitability are controversial. We investigated the effects of intracortical injections of orexin A (100 pmol) and B (100 pmol) on the electrophysiological manifestation of epileptic seizures induced by cortical penicillin application in adult male rats. In comparison to saline, orexin A and B enhanced significantly the spike number, spike amplitude and spectral power values induced by cortical penicillin. Our findings indicates that orexins enhances the hyperexcitable and hypersyncronic cortical epileptic activity induced by focal application of penicillin-G. © 2012 Elsevier Inc. All rights reserved. ; 2003SBE001 ; This study was supported by Pamukkale University Research Fund ( 2003SBE001 ). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0196-9781 |
| العلاقة: | Peptides; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1016/j.peptides.2012.02.013Test; https://hdl.handle.net/20.500.12438/5209Test; 34; 419; 422 |
| DOI: | 10.1016/j.peptides.2012.02.013 |
| الإتاحة: | https://doi.org/20.500.12438/5209Test https://doi.org/10.1016/j.peptides.2012.02.013Test https://hdl.handle.net/20.500.12438/5209Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.EC2FF828 |
| قاعدة البيانات: | BASE |
| تدمد: | 01969781 |
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| DOI: | 10.1016/j.peptides.2012.02.013 |