دورية أكاديمية

The effects of midazolam and etomidate on the antioxidant system in the rat liver

التفاصيل البيبلوغرافية
العنوان: The effects of midazolam and etomidate on the antioxidant system in the rat liver
المؤلفون: Bayram D., Öncü M., Uz E., Yilmaz H.R., Yiğit A., Koçak A.
بيانات النشر: Scientific and Technical Research Council of Turkey
سنة النشر: 2015
المجموعة: Kütahya Dumlupınar University Institutional Repository
مصطلحات موضوعية: Catalase, Etomidate, Liver, Malondialdehyde, Midazolam, Superoxide dismutase
الوصف: This study was conducted to investigate the histopathological and biochemical effects of midazolam and etomidate, which are intravenous anesthetics used in surgical operations, on rat liver. There were 3 study groups each consisting of 9 animals: the control, midazolam, and etomidate groups. Midazolam and etomidate were administered 10 times with 1-day intervals. At the end of the study, tissues were taken for histological examination and biochemical analysis. We determined superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) levels in the liver. There was a slight increase in MDA level in the midazolam-exposed group when compared with the controls, and this was not statistically significant. However, SOD and CAT activities were significantly increased in the midazolam group. We found slight damage in histological sections in parallel to biological findings. MDA levels were significantly increased in the etomidate group and SOD and CAT activities were also prominent in this group. More histological changes like hepatocyte degeneration, vascular congestion, and mononuclear cell infiltration were observed in the etomidate group and this was statistically significant. We can say that these intravenous anesthetic agents may cause dose-dependent damage in tissue. Therefore, we think that one must be cautious of the administration duration and dose levels of anesthetics during surgical operations. © TÜBİTAK
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1300-0152
العلاقة: Turkish Journal of Biology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.3906/biy-1505-47Test; https://hdl.handle.net/20.500.12438/7857Test; 39; 865; 871
DOI: 10.3906/biy-1505-47
الإتاحة: https://doi.org/20.500.12438/7857Test
https://doi.org/10.3906/biy-1505-47Test
https://hdl.handle.net/20.500.12438/7857Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.D17E6C37
قاعدة البيانات: BASE
الوصف
تدمد:13000152
DOI:10.3906/biy-1505-47