التفاصيل البيبلوغرافية
| العنوان: |
Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts |
| المؤلفون: |
Yuka, Maeyama, Yuta, Nakashima, Hikaru, Kato, Yuki, Hitora, Kazuhiko Maki, Natsumi, Inada, Shunya, Murakami, Tomoaki, Inazumi, Yuji, Ise, Yukihiko, Sugimoto, Hayato, Ishikawa, Sachiko, Tsukamoto, 塚本, 佐知子, ツカモト, サチコ |
| سنة النشر: |
2021 |
| المجموعة: |
Kumamoto University Repository |
| الوصف: |
A simple methylenedioxy dibromoindole alkaloid, amakusamine (1), was isolated from a marine sponge of the genus Psammocinia, and its structure was determined from spectroscopic data, time-dependent density-functional theory calculations, and synthesis. Compound 1 inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC50 value of 10.5 μM in RAW264 cells. The structure-activity relationship of 1 was also investigated with synthetic derivatives. ; journal article |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0163-3864 |
| العلاقة: |
https://doi.org/10.1021/acs.jnatprod.1c00758Test; Journal of Natural Products; 10; 84; 2738; 2743; https://kumadai.repo.nii.ac.jp/record/2000054/files/acs_jnatprod_1c00758.pdfTest |
| الإتاحة: |
https://doi.org/10.1021/acs.jnatprod.1c00758Test
https://kumadai.repo.nii.ac.jp/record/2000054/files/acs_jnatprod_1c00758.pdfTest |
| حقوق: |
(C)2021 American Chemical Society and American Society of Pharmacognosy ; This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in [Journal of Natural Products], copyright (C)2021 American Chemical Society and American Society of Pharmacognosy after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.jnatprod.1c00758Test |
| رقم الانضمام: |
edsbas.4B1F36F7 |
| قاعدة البيانات: |
BASE |
