دورية أكاديمية
A case of probable Vogt-Koyanagi-Harada disease in a 3-year-old girl
| العنوان: | A case of probable Vogt-Koyanagi-Harada disease in a 3-year-old girl |
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| المؤلفون: | Katsuyama, Atsuko, Kusuhara, Sentaro, Awano, Hiroyuki, Nagase, Hiroaki, Matsumiya, Wataru, Nakamura, Makoto |
| بيانات النشر: | BMC |
| سنة النشر: | 2019 |
| المجموعة: | Kobe University Repository (Kernel) / 神戸大学学術成果リポジトリ |
| مصطلحات موضوعية: | Vogt-Koyanagi-Harada disease, Child, Uveitis, Corticosteroid therapy |
| الوصف: | Background Vogt-Koyanagi-Harada (VKH) disease is a T-cell-mediated autoimmune disorder characterized by bilateral granulomatous panuveitis with various systemic manifestations. Although VKH disease rarely occurs in the pediatric population, the clinical course tends to be aggressive, and the visual prognosis is worse than that in adult patients due to severe ocular complications secondary to recurrent inflammation. Case presentation A 3-year-old girl with probable VKH was referred to Kobe University Hospital. She had severe bilateral panuveitis with posterior synechiae of the iris, marked optic disk swelling, and serous retinal detachment in both eyes, and her best corrected visual acuities (BCVAs) were 20/200 OD and 20/125 OS. A third course of therapy was administered because serous retinal detachment remained after two courses of therapy. She was treated with three courses of high-dose intravenous corticosteroid therapy, followed by slow tapering of oral corticosteroids. Her BCVAs recovered to 20/16 OU, and relapse of ocular inflammation and side effect of treatment were not observed during the 1.5-year follow-up period. Conclusions We experienced a pediatric patient with probable VKH disease who was treated with three courses of high-dose intravenous corticosteroid therapy. With the favorable clinical course in our patient, initial treatment with repeated high-dose intravenous corticosteroid therapy might be beneficial in pediatric VKH disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:doi/10.1186/s12886-019-1192-0 |
| الإتاحة: | http://www.lib.kobe-u.ac.jp/handle_kernel/90006295Test http://www.lib.kobe-u.ac.jp/repository/90006295.pdfTest |
| حقوق: | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0Test/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0Test/) applies to the data made available in this article, unless otherwise stated. |
| رقم الانضمام: | edsbas.9E8942E5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |