دورية أكاديمية
Increased burden of familial-associated early-onset cancer risk among minority americans compared to non-latino whites
| العنوان: | Increased burden of familial-associated early-onset cancer risk among minority americans compared to non-latino whites |
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| المؤلفون: | Feng, Qianxi, Nickels, Eric, Muskens, Ivo S., de Smith, Adam J., Gauderman, W. James, Yee, Amy C., Ricker, Charite, Mack, Thomas, Leavitt, Andrew D., Godley, Lucy A., Wiemels, Joseph L. |
| المصدر: | http://knowledge.uchicago.edu/record/9864Test. |
| سنة النشر: | 2023 |
| المجموعة: | Knowledge@UChicago (University of Chicago) |
| الوصف: | Background: The role of race/ethnicity in genetic predisposition of early-onset cancers can be estimated by comparing family-based cancer concordance rates among ethnic groups. Methods: We used linked California health registries to evaluate the relative cancer risks for first-degree relatives of patients diagnosed between ages 0 and 26, and the relative risks of developing distinct second primary malignancies (SPMs). From 1989 to 2015, we identified 29,631 cancer patients and 62,863 healthy family members. We calculated the standardized incident ratios (SIRs) of early-onset primary cancers diagnosed in proband siblings and mothers, as well as SPMs detected among early-onset patients. Analyses were stratified by self-identified race/ethnicity. Results: Given probands with cancer, there were increased relative risks of any cancer for siblings and mothers (SIR = 3.32; 95% confidence interval [CI]: 2.85–3.85) and of SPMs (SIR = 7.27; 95% CI: 6.56–8.03). Given a proband with solid cancer, both Latinos (SIR = 4.98; 95% CI: 3.82–6.39) and non-Latino Blacks (SIR = 7.35; 95% CI: 3.36–13.95) exhibited significantly higher relative risk of any cancer in siblings and mothers when compared to non-Latino White subjects (SIR = 3.02; 95% CI: 2.12–4.16). For hematologic cancers, higher familial risk was evident for Asian/Pacific Islanders (SIR = 7.56; 95% CI: 3.26–14.90) compared to non-Latino whites (SIR = 2.69; 95% CI: 1.62–4.20). Conclusions: The data support a need for increased attention to the genetics of early-onset cancer predisposition and environmental factors in race/ethnic minority families in the United States. |
| نوع الوثيقة: | text |
| اللغة: | English |
| العلاقة: | https://knowledge.uchicago.edu/record/9864/files/elife-64793-v1.pdfTest; https://knowledge.uchicago.edu/record/9864/files/elife-64793.zipTest; http://knowledge.uchicago.edu/record/9864Test |
| DOI: | 10.7554/eLife.64793 |
| الإتاحة: | https://doi.org/10.7554/eLife.64793Test http://knowledge.uchicago.edu/record/9864Test |
| رقم الانضمام: | edsbas.4D2D32B4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/eLife.64793 |
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