دورية أكاديمية
Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species.
| العنوان: | Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species. |
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| المؤلفون: | Claudio Donati, Natalia Hiller, Herve Tettelin, Alessandro Muzzi, Nicholas J. Croucher, Samuel V. Angiuoli, Marco Oggioni, Julie C. Dunning Hotopp, Fen Z. Hu, David R. Riley, Antonello Covacci, Tim J. Mitchell, Stephen D. Bentley, Morgens Kilian, Garth D. Ehrlich, Rino Rappuoli, E. Richard Moxon, Vega Masignani |
| سنة النشر: | 2018 |
| المجموعة: | KiltHub Research from Carnegie Mellon University |
| مصطلحات موضوعية: | Biological Sciences not elsewhere classified, DNA, Bacterial, Evolution, Molecular, Gene Conversion, Genes, Genetic Variation, Genome, Linkage Disequilibrium, Multigene Family, Phylogeny, Polymorphism, Single Nucleotide, Sequence Alignment, Sequence Analysis, Streptococcus mitis, Streptococcus pneumoniae, Virulence |
| الوصف: | BACKGROUND: Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group. RESULTS: Despite evidence of extensive recombination, the S. pneumoniae phylogenetic tree revealed six major lineages. With the exception of serotype 1, the tree correlated poorly with capsular serotype, geographical site of isolation and disease outcome. The distribution of dispensable genes--genes present in more than one strain but not in all strains--was consistent with phylogeny, although horizontal gene transfer events attenuated this correlation in the case of ancient lineages. Homologous recombination, involving short stretches of DNA, was the dominant evolutionary process of the core genome of S. pneumoniae. Genetic exchange occurred both within and across the borders of the species, and S. mitis was the main reservoir of genetic diversity of S. pneumoniae. The pan-genome size of S. pneumoniae increased logarithmically with the number of strains and linearly with the number of polymorphic sites of the sampled genomes, suggesting that acquired genes accumulate proportionately to the age of clones. Most genes associated with pathogenicity were shared by all S. pneumoniae strains, but were also present in S. mitis, S. oralis and S. infantis, indicating that these genes are not sufficient to determine virulence. CONCLUSIONS: Genetic exchange with related species sharing the same ecological niche is the main mechanism of evolution of S. pneumoniae. The open pan-genome guarantees the species a quick and economical response to diverse environments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/Structure_and_dynamics_of_the_pan-genome_of_Streptococcus_pneumoniae_and_closely_related_species_/6104375Test |
| DOI: | 10.1184/r1/6104375.v1 |
| الإتاحة: | https://doi.org/10.1184/r1/6104375.v1Test https://figshare.com/articles/Structure_and_dynamics_of_the_pan-genome_of_Streptococcus_pneumoniae_and_closely_related_species_/6104375Test |
| حقوق: | CC BY 3.0 |
| رقم الانضمام: | edsbas.66866794 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1184/r1/6104375.v1 |
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