دورية أكاديمية
Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity.
| العنوان: | Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity. |
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| المؤلفون: | Graziella Di Cristo, Bidisha Chattopadhyaya, Sandra Kuhlman, Yu Fu, Marie-Claude Bélanger, Cai Zhi Wu, Urs Rutishauser, Lamberto Maffei, Z. Josh Huang |
| سنة النشر: | 2018 |
| المجموعة: | KiltHub Research from Carnegie Mellon University |
| مصطلحات موضوعية: | Biological Sciences not elsewhere classified, Age Factors, Analysis of Variance, Anesthetics, Local, Animals, Newborn, Critical Period (Psychology), Evoked Potentials, Visual, Gene Expression Regulation, Developmental, Glutamate Decarboxylase, Glycoside Hydrolases, Green Fluorescent Proteins, Mice, Neural Cell Adhesion Molecules, Neural Inhibition, Neuronal Plasticity, Photic Stimulation, Sensory Deprivation, Sialic Acids, Tetrodotoxin, Visual Cortex, Visual Pathways, gamma-Aminobutyric Acid |
| الوصف: | Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here we show that polysialic acid (PSA), presented by the neural cell adhesion molecule, has a role in the maturation of GABAergic innervation and ocular dominance plasticity. Concentrations of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this decline is hindered by visual deprivation. The developmental and activity-dependent regulation of PSA expression is inversely correlated with the maturation of GABAergic innervation. Premature removal of PSA in visual cortex results in precocious maturation of perisomatic innervation by basket interneurons, enhanced inhibitory synaptic transmission, and earlier onset of ocular dominance plasticity. The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/Activity-dependent_PSA_expression_regulates_inhibitory_maturation_and_onset_of_critical_period_plasticity_/6097184Test |
| DOI: | 10.1184/r1/6097184.v1 |
| الإتاحة: | https://doi.org/10.1184/r1/6097184.v1Test https://figshare.com/articles/Activity-dependent_PSA_expression_regulates_inhibitory_maturation_and_onset_of_critical_period_plasticity_/6097184Test |
| حقوق: | In Copyright |
| رقم الانضمام: | edsbas.41648199 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1184/r1/6097184.v1 |
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