دورية أكاديمية
Firing properties of GABAergic versus non-GABAergic vestibular nucleus neurons conferred by a differential balance of potassium currents.
| العنوان: | Firing properties of GABAergic versus non-GABAergic vestibular nucleus neurons conferred by a differential balance of potassium currents. |
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| المؤلفون: | Aryn Gittis, Sascha du Lac |
| سنة النشر: | 2018 |
| المجموعة: | KiltHub Research from Carnegie Mellon University |
| مصطلحات موضوعية: | Biological Sciences not elsewhere classified, Action Potentials, Anesthetics, Local, Animals, Newborn, Calcium, Dose-Response Relationship, Radiation, Electric Stimulation, Luminescent Proteins, Mice, Inbred C57BL, Inbred ICR, Transgenic, Neurons, Patch-Clamp Techniques, Peptides, Potassium Channel Blockers, Potassium Channels, Tetraethylammonium, Tetrodotoxin, Vestibular Nuclei, gamma-Aminobutyric Acid |
| الوصف: | Neural circuits are composed of diverse cell types, the firing properties of which reflect their intrinsic ionic currents. GABAergic and non-GABAergic neurons in the medial vestibular nuclei, identified in GIN and YFP-16 lines of transgenic mice, respectively, exhibit different firing properties in brain slices. The intrinsic ionic currents of these cell types were investigated in acutely dissociated neurons from 3- to 4-wk-old mice, where differences in spontaneous firing and action potential parameters observed in slice preparations are preserved. Both GIN and YFP-16 neurons express a combination of four major outward currents: Ca(2+)-dependent K(+) currents (I(KCa)), 1 mM TEA-sensitive delayed rectifier K(+) currents (I(1TEA)), 10 mM TEA-sensitive delayed rectifier K(+) currents (I(10TEA)), and A-type K(+) currents (I(A)). The balance of these currents varied across cells, with GIN neurons tending to express proportionately more I(KCa) and I(A), and YFP-16 neurons tending to express proportionately more I(1TEA) and I(10TEA). Correlations in charge densities suggested that several currents were coregulated. Variations in the kinetics and density of I(1TEA) could account for differences in repolarization rates observed both within and between cell types. These data indicate that diversity in the firing properties of GABAergic and non-GABAergic vestibular nucleus neurons arises from graded differences in the balance and kinetics of ionic currents. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/Firing_properties_of_GABAergic_versus_non-GABAergic_vestibular_nucleus_neurons_conferred_by_a_differential_balance_of_potassium_currents_/6098981Test |
| DOI: | 10.1184/r1/6098981.v1 |
| الإتاحة: | https://doi.org/10.1184/r1/6098981.v1Test https://figshare.com/articles/Firing_properties_of_GABAergic_versus_non-GABAergic_vestibular_nucleus_neurons_conferred_by_a_differential_balance_of_potassium_currents_/6098981Test |
| حقوق: | In Copyright |
| رقم الانضمام: | edsbas.677E34F8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1184/r1/6098981.v1 |
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