دورية أكاديمية
Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses
| العنوان: | Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses |
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| المؤلفون: | Nakamura Mitsuhiro, Bodily Jason M., Beglina Melanie, Kyo Satoru, Inoue Masaki, Laimins Laimonis A. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2009 |
| المجموعة: | Kanazawa University Repository for Academic Resources (KURA) / 金沢大学学術情報リポジトリ |
| مصطلحات موضوعية: | Angiogenesis, Carbonic anhydrase (CAIX), Deferoxamine mesylate (DFO), Hypoxia, Hypoxia inducible factor-1 (HIF-1), Keratinocytes, Papillomaviruses (HPV), Vascular endothelial growth factor (VEGF) |
| الوصف: | 金沢大学附属病院産科婦人科 ; Human papillomaviruses (HPV) are the causative agents of cervical cancer and have been shown to increase expression of pro-angiogenic factors from infected cells. Many angiogenic factors are regulated by hypoxia inducible factor 1α (HIF-1α). We investigated whether HPV31 affects the levels of HIF-1α under normal and hypoxic conditions. Our studies indicate that cells containing complete HPV31 genomes showed enhanced levels of HIF-1α upon treatment with the hypoxia mimic DFO, which resulted from protein stabilization and led to increased expression of some but not all HIF-1α target genes. Both HPV E6 and E7 were able independently to enhance induction of HIF-1α upon DFO treatment. Enhancement of HIF-1α stability was not restricted to high-risk HPV types, as HPV11, a low risk HPV type, mediated a similar effect. These findings shed light on mechanisms by which HPV contributes to angiogenesis both in benign cervical lesions and in cervical cancers. © 2009 Elsevier Inc. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0042-6822 |
| العلاقة: | http://www.elsevier.com/locate/issn/00426822Test; https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=27016Test; http://hdl.handle.net/2297/17396Test; Virology, 387(2), 442-448(2009-05-10); AA00884454; https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27016&item_no=1&attribute_id=26&file_no=1Test |
| الإتاحة: | http://hdl.handle.net/2297/17396Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=27016Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27016&item_no=1&attribute_id=26&file_no=1Test |
| رقم الانضمام: | edsbas.5D643294 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00426822 |
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