دورية أكاديمية
Changes in calbindin-D28k and parvalbumin expression in the superior olivary complex following unilateral cochlear ablation in neonatal rats
| العنوان: | Changes in calbindin-D28k and parvalbumin expression in the superior olivary complex following unilateral cochlear ablation in neonatal rats |
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| المؤلفون: | Hatano Miyako, Furukawa Mitsuru, Ito Makoto |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2009 |
| المجموعة: | Kanazawa University Repository for Academic Resources (KURA) / 金沢大学学術情報リポジトリ |
| مصطلحات موضوعية: | Calcium-binding protein, Cochlear nucleus (CN), Development, Superior olivary complex (SOC), Unilateral cochlear ablation |
| الوصف: | 金沢大学医薬保健研究域医学系 ; Conclusion. Unilateral congenital deafness with a volume reduction in cochlear nucleus (CN) induced changes in the calcium-binding proteins (CaBPs) in the contralateral superior olivary complex (SOC) in the rat. With the loss of neurons and a volume reduction in the CN, a decrease in the input to the contralateral SOC may occur, which results in the down-regulation of CaBPs in these nuclei. This study may provide some implications regarding the neurochemistry in the auditory brainstem of deaf children. Objective. Hearing loss produced by cochlear damage during early development can result in persistent changes in the organization of the central auditory system in adults. The purpose of the present study was to investigate the neurochemical changes produced in the auditory brainstem of rats with unilateral cochlear ablation conducted before the onset of hearing. Materials and methods. Following unilateral cochlear ablation during early development, we examined the changes in the distribution of two CaBPs, calbindin-D28k (CB) and parvalbumin (PV), in the SOC. Results. Upon reaching adulthood, a marked decrease in CB- and PV-immunoreactive neurons was observed in the contralateral SOC, particularly in the medial nucleus of the trapezoid body (MNTB), although no neuronal cell death was observed. A volume reduction in the ipsilateral CN was also observed. © 2009 Informa UK Ltd. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0001-6489 |
| العلاقة: | https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=14602Test; http://hdl.handle.net/2297/19812Test; Acta Oto-Laryngologica, 129(8), 839-845(2009-01-01); AA0050923X; https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=14602&item_no=1&attribute_id=26&file_no=1Test |
| الإتاحة: | http://hdl.handle.net/2297/19812Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=14602Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=14602&item_no=1&attribute_id=26&file_no=1Test |
| رقم الانضمام: | edsbas.128A6E40 |
| قاعدة البيانات: | BASE |
| تدمد: | 00016489 |
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