دورية أكاديمية
The role of nuclear pore complex in tumor microenvironment and metastasis
| العنوان: | The role of nuclear pore complex in tumor microenvironment and metastasis |
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| المؤلفون: | Funasaka Tatsuyoshi, Wong Richard W., 船坂 龍善 |
| بيانات النشر: | Springer Science+Business Media, LLC |
| سنة النشر: | 2011 |
| المجموعة: | Kanazawa University Repository for Academic Resources (KURA) / 金沢大学学術情報リポジトリ |
| مصطلحات موضوعية: | Beta-catenin, EGFR, HIF-1, Metastasis, microRNA, NF kappa B, Nuclear pore complex, Nucleoporins, Smad, TGF beta, Tumor microenvironment |
| الوصف: | 金沢大学フロンティアサイエンス機構 ; One of the main reasons for cancer mortality is caused by the highly invasive behavior of cancer cells, which often due to aggressive metastasis. Metastasis is mediated by various growth factors and cytokines, operating through numerous signaling pathways. Remarkably, all these metastatic signaling pathways must enter the nucleus through a single gatekeeper, the nuclear pore complex (NPC). NPCs are the only gateway between the cytoplasm and the nucleus. NPCs are among the largest proteinaceous assemblies in the cell and are composed of multiple copies of around 30 different proteins called nucleoporins. Here, we review what is currently known about the NPC, and its role in the mechanisms of tumor progression. We will also explore potential strategies to target metastatic pathways by manipulating the karyopherins (importins/exportins) of nucleocytoplasmic traffic through NPCs. © 2011 Springer Science+Business Media, LLC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0167-7659 |
| العلاقة: | https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=40006Test; http://hdl.handle.net/2297/26611Test; Cancer and Metastasis Reviews, 30(2), 239-251(2011-06-01); AA10673193; https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=40006&item_no=1&attribute_id=26&file_no=1Test |
| الإتاحة: | http://hdl.handle.net/2297/26611Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=40006Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=40006&item_no=1&attribute_id=26&file_no=1Test |
| رقم الانضمام: | edsbas.56E8CECC |
| قاعدة البيانات: | BASE |
| تدمد: | 01677659 |
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