دورية أكاديمية
A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children : the PANIC study
| العنوان: | A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children : the PANIC study |
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| المؤلفون: | Lakka,Timo A., Lintu, Niina, Väistö, Juuso, Viitasalo, Anna, Sallinen, Taisa, Haapala, Eero A., Tompuri, Tuomo T., Soininen, Sonja, Karjalainen, Panu, Schnurr, Theresia M., Mikkonen, Santtu, Atalay, Mustafa, Kilpeläinen, Tuomas O., Laitinen, Tomi, Laaksonen, David E., Savonen, Kai, Brage, Soren, Schwab, Ursula, Jääskeläinen, Jarmo, Lindi, Virpi, Eloranta, Aino-Maija |
| بيانات النشر: | Springer |
| سنة النشر: | 2020 |
| المجموعة: | JYX - Jyväskylä University Digital Archive / Jyväskylän yliopiston julkaisuarkisto |
| مصطلحات موضوعية: | body fat, children, diet, glucose, HOMA-IR, insulin, intervention, lean body mass, physical activity, sedentary time, ruokavaliot, lapset (ikäryhmät), insuliini, fyysinen aktiivisuus, kehonkoostumus, interventiotutkimus, glukoosi |
| الوصف: | Aims/hypothesis We studied for the first time the long-term effects of a combined physical activity and dietary intervention on insulin resistance and fasting plasma glucose in a general population of predominantly normal-weight children. Methods We carried out a 2 year non-randomised controlled trial in a population sample of 504 children aged 6–9 years at baseline. The children were allocated to a combined physical activity and dietary intervention group (306 children at baseline, 261 children at 2-year follow-up) or a control group (198 children, 177 children) without blinding. We measured fasting insulin and fasting glucose, calculated HOMA-IR, assessed physical activity and sedentary time by combined heart rate and body movement monitoring, assessed dietary factors by a 4 day food record, used the Finnish Children Healthy Eating Index (FCHEI) as a measure of overall diet quality, and measured body fat percentage (BF%) and lean body mass by dual-energy x-ray absorptiometry. The intervention effects on insulin, glucose and HOMA-IR were analysed using the intention-to-treat principle and linear mixed-effects models after adjustment for sex, age at baseline, and pubertal status at baseline and 2 year follow-up. The measures of physical activity, sedentary time, diet and body composition at baseline and 2 year follow-up were entered one-by-one as covariates into the models to study whether changes in these variables might partly explain the observed intervention effects. Results Compared with the control group, fasting insulin increased 4.65 pmol/l less (absolute change +8.96 vs +13.61 pmol/l) and HOMA-IR increased 0.18 units less (+0.31 vs +0.49 units) over 2 years in the combined physical activity and dietary intervention group. The intervention effects on fasting insulin (regression coefficient β for intervention effect −0.33 [95% CI −0.62, −0.04], p = 0.026) and HOMA-IR (β for intervention effect −0.084 [95% CI −0.156, −0.012], p = 0.023) were statistically significant after adjustment for sex, age at ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; 2270-2281; fulltext |
| اللغة: | English |
| تدمد: | 0012-186X |
| العلاقة: | Diabetologia; 11; 63; Lakka, T. A., Lintu, N., Väistö, J., Viitasalo, A., Sallinen, T., Haapala, E. A., Tompuri, T. T., Soininen, S., Karjalainen, P., Schnurr, T. M., Mikkonen, S., Atalay, M., Kilpeläinen, T. O., Laitinen, T., Laaksonen, D. E., Savonen, K., Brage, S., Schwab, U., Jääskeläinen, J., . . . Eloranta, A.-M. (2020). A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children : the PANIC study. Diabetologia , 63 (11), 2270-2281. https://doi.org/10.1007/s00125-020-05250-0Test; CONVID_41792401; URN:NBN:fi:jyu-202008265651; http://urn.fi/URN:NBN:fi:jyu-202008265651Test |
| الإتاحة: | https://doi.org/10.1007/s00125-020-05250-0Test http://urn.fi/URN:NBN:fi:jyu-202008265651Test |
| حقوق: | CC BY 4.0 ; © 2020 the Authors ; openAccess ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.45E03254 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 0012186X |
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