التفاصيل البيبلوغرافية
| العنوان: |
Biomarkers in esophageal cancer |
| المؤلفون: |
Takala, H. (Heikki) |
| المساهمون: |
Soini, Y. (Ylermi), Karttunen, T. (Tuomo), Saarnio, J. (Juha) |
| بيانات النشر: |
Oulun yliopisto |
| سنة النشر: |
2012 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| مصطلحات موضوعية: |
angiogenesis, claudin, esophageal cancer, hypoxia inducible factor-1α (HIF-1α), nitric oxide synthase (NOS), toll-like receptor 9 (TLR9), vascular endothelial growth factor (VEGF), hypoksia-indusoituva tekijä 1α (HIF-1α), klaudiini, ruokatorvisyöpä, tollin kaltainen reseptori 9 (TLR9), typpioksidisyntaasi (NOS), verisuonen endoteelin kasvutekijä (VEGF), verisuonten uudismuodostus |
| الوصف: |
Mediators of epithelial permeability, angiogenesis and invasion may serve as prognostic indicators and targets for therapies in esophageal cancer (EC). The expressions of claudins, hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor-A (VEGF), nitric oxide synthases (iNOS, eNOS, nNOS) and toll-like receptor 9 (TLR9) were evaluated by immunohistochemistry in EC. The results were compared with clinicopathological variables, tumor proliferation and apoptosis. All of the claudins were expressed in most of the cancers. Esophageal adenocarcinomas (EAC) displayed more often increased claudin 3 and 5 expression than esophageal squamous cell carcinomas (ESCC). Loss of claudin 3 expression associated with distant metastases in EC and a tendency in this direction was also observed for claudin 4. Cancers with stronger claudin 4 expression showed increased apoptosis in both EAC and ESCC. HIF-1α was present in most of the ECs and like iNOS more often in ESCC than in EAC. Strong HIF-1α expression tended to associate with positive VEGF immunostaining. In ESCC, both strong HIF-1α expression and VEGF positivity tended to associate with increased microvessel density (MVD). In EAC, tumors showing VEGF positivity associated with increased MVD outside the tumor. Patients with strong HIF-1α expression had more often distant metastases than other patients in EC. There was no VEGF expression in normal esophageal mucosa and T3-4 tumors tended to be more often VEGF positive than T1-2 tumors. The expression of TLR9 was more intensive in dysplasia than in normal epithelium and ESCC and abundant TLR9 expression could serve as a marker of squamous cell high grade dysplasia. Intensive TLR9 expression was associated with higher grade tumors and the presence of nodal and distant metastases in ESCC. EC and its progression may be related to increased angiogenesis regulated by VEGF and HIF-1α. In EC, claudin expression varies along with the histology of the tumor. Claudin expression may be associated with apoptosis or ... |
| نوع الوثيقة: |
doctoral or postdoctoral thesis |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/pissn/0355-3221; info:eu-repo/semantics/altIdentifier/eissn/1796-2234 |
| الإتاحة: |
http://urn.fi/urn:isbn:9789514298400Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © University of Oulu, 2012 |
| رقم الانضمام: |
edsbas.84384544 |
| قاعدة البيانات: |
BASE |
