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1دورية أكاديمية
المؤلفون: Dimopoulos, Meletios A., Opat, Stephen, D'Sa, Shirley, Jurczak, Wojciech, Lee, Hui-Peng, Cull, Gavin, Owen, Roger G., Marlton, Paula, Wahlin, Bjorn E., Garcia-Sanz, Ramon, McCarthy, Helen, Mulligan, Stephen, Tedeschi, Alessandra, Castillo, Jorge J., Czyz, Jaroslaw, Fernández de Larrea, Carlos, Belada, David, Libby, Edward, Matous, Jeffrey, Motta, Marina, Siddiqi, Tanya, Tani, Monica, Trneny, Marek, Minnema, Monique C., Buske, Christian, Leblond, Veronique, Treon, Steven P., Trotman, Judith, Chan, Wai Y., Schneider, Jingjing, Allewelt, Heather, Patel, Sheel, Cohen, Aileen, Tam, Constantine S.
العلاقة: Journal of Clinical Oncology, T. 41, nr 33, s. 5099-5106; https://ruj.uj.edu.pl/xmlui/handle/item/317304Test
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2دورية أكاديمية
المؤلفون: Tam, Constantine S, Dimopoulos, Meletios A., Garcia-Sanz, Ramon, Trotman, Judith, Opat, Stephen, Roberts, Andrew W, Owen, Roger G., Song, Yuqin, Xu, Wei, Zhu, Jun, Li, Jianyong, Qiu, Lugui, D'Sa, Shirley, Jurczak, Wojciech, Cull, Gavin, Marlton, Paula, Gottlieb, David J, Munoz, Javier, Phillips, Tycel, Du, Chenmu, Ji, Meng, Zhou, Lei, Guo, Haiyi, Zhu, Hongjie, Chan, Wai Y., Cohen, Aileen, Novotny, William, Huang, Jane, Tedeschi, Alessandra
مصطلحات موضوعية: zanubrutinib, bruton tyrosine kinase, B-cell malignancy, safety
الوصف: Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor evaluated in multiple B-cell malignancy studies. We constructed a pooled safety analysis to better understand zanubrutinib-associated treatment-emergent adverse events (TEAEs) and identify treatment-limiting toxicities. Data were pooled from 6 studies (N=779). Assessments included type, incidence, severity, and outcome of TEAEs. Median age was 65 years; 20% were ≥75 years old. Most patients had Waldenström macroglobulinemia (33%), chronic lymphocytic leukemia/small lymphocytic lymphoma (29%), or mantle-cell lymphoma (19%). Median treatment duration was 26 months (range: 0.1-65); 16% of patients were treated for ≥3 years. Common nonhematologic TEAEs were upper respiratory tract infection (URI, 39%), rash (27%), bruising (25%), musculoskeletal pain (24%), diarrhea (23%), cough, pneumonia (21% each), urinary tract infection (UTI), fatigue (15% each). Most common grade ≥3 TEAEs were pneumonia (11%), hypertension (5%), URI, UTI, sepsis, diarrhea, and musculoskeletal pain (2% each). Atrial fibrillation and major hemorrhage occurred in 3% and 4% of patients, respectively. Atrial fibrillation, hypertension and diarrhea occurred at lower rates than those reported historically for ibrutinib. Grade ≥3 AEs included neutropenia (23%), thrombocytopenia (8%), and anemia (8%). Serious TEAEs included pneumonia (11%), sepsis (2%), and pyrexia (2%). Treatment discontinuations and dose reductions for AEs occurred in 10% and 8% of patients, respectively. Thirty-nine patients (4%) had fatal TEAEs, including pneumonia (n=9), sepsis (n=4), unspecified cause (n=4), and multiple organ dysfunction syndrome (n=5). This analysis demonstrates that zanubrutinib is generally well tolerated with a safety profile consistent with known BTK inhibitor toxicities; these were manageable and mostly reversible.
العلاقة: Blood Advances, T. 6, nr 4, s. 1296-1308; https://ruj.uj.edu.pl/xmlui/handle/item/287991Test
الإتاحة: https://doi.org/10.1182/bloodadvances.2021005621Test
https://ruj.uj.edu.pl/xmlui/handle/item/287991Test -
3دورية أكاديمية
المؤلفون: Furman, Richard R., Byrd, John C., Owen, Roger G., Obrien, Susan M., Brown, Jennifer R., Hillmen, Peter, Stephens, Deborah M., Chernyukhin, Nataliya, Lezhava, Tamara, Hamdy, Ahmed M., Izumi, Raquel, Patel, Priti, Baek, Marshall, Christian, Beth, Dyer, Martin J. S., Streetly, Matthew J., Sun, Clare, Rule, Simon, Wang, Michael, Ghia, Paolo, Jurczak, Wojciech, Pagel, John M., Sharman, Jeff P.
العلاقة: Leukemia, T. 35, nr 11, s. 3201-3211; https://ruj.uj.edu.pl/xmlui/handle/item/290017Test
الإتاحة: https://doi.org/10.1038/s41375-021-01252-yTest
https://ruj.uj.edu.pl/xmlui/handle/item/290017Test -
4دورية أكاديمية
المؤلفون: Tam, Constantine S., Opat, Stephen, D'Sa, Shirley, Jurczak, Wojciech, Lee, Hui-Peng, Cull, Gavin, Owen, Roger G., Marlton, Paula Marlton, Wahlin, Björn E., Garcia Sanz, Ramon, Mccarthy, Helen, Mulligan, Stephen, Tedeschi, Alessandra, Castillo, Jorge J., Czyz, Jaroslaw, de Larrea, Carlos Fernandez, Belada, David, Libby, Edward, Matous, Jeffrey, Motta, Marina, Siddiqi, Tanya, Tani, Monica, Trneny, Marek, Minnema, Monique C., Buske, Christian, Leblond, Veronique, Trotman, Judith, Chan, Wai Y., Schneider, Jingjing, Ro, Sunhee, Cohen, Aileen, Huang, Jane, Dimopoulos, Meletios
العلاقة: Blood, T. 136, nr 18, s. 2038-2050; https://ruj.uj.edu.pl/xmlui/handle/item/320459Test
الإتاحة: https://doi.org/10.1182/blood.2020006844Test
https://ruj.uj.edu.pl/xmlui/handle/item/320459Test