دورية أكاديمية
Proteomic analysis of liver preservation solutions prior to liver transplantation
| العنوان: | Proteomic analysis of liver preservation solutions prior to liver transplantation |
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| المؤلفون: | Coşkun, Abdurrahman, Baykal, Ahmet Tarık, Öztuğ, Merve, Kazan, Dilek, Kaya, Ekrem, Emiroğlu, Remzi, Yılmaz, Sezai, Dündar, Halit Ziya, Akgöz, Müslüm, Berber, İbrahim, Ak-taş, Hikmet, Bilsel, Gökhan, Karaosmanoğlu, Kübra, Çetiner, Banu, Arslan, Cansu, Yurtsever, İlknur, Yazıcı, Cevat |
| بيانات النشر: | Bentham Science Publishers Ltd. |
| سنة النشر: | 2019 |
| المجموعة: | İstanbul Medipol University Institutional Repository (DSpace@Medipol) |
| مصطلحات موضوعية: | Liver, Mass Spectrometry, Organ Preservation Solution, Proteomics, Liver Transplantation, Hypothermia |
| الوصف: | WOS: 000458615900004 ; Objective: Transplantation is the preferred treatment for patients with endstage liver diseases. However, in clinical practice, functional preservation of the liver is a major concern before the transplantation. Although various protective solutions are used (in combination with hypothermia), the functional preservation time for liver is still limited to hours. We analyzed the preservation medium to detect the proteins released from the liver during storage period. Material/Methods: Samples were collected from the pretransplant preservation mediums of 23 liver donors. For all donors, the cases involved Donation after Brain Death (DBD). 2D-PAGE and LC-MSMS methodologies were used to detect the proteins and peptides from the preservation mediums. Results: A total of 198 proteins originating from the liver were detected. Conclusion: The data provide valuable insights into biomarkers that may be used to evaluate organ injury, functional status, and suitability for transplantation. Additionally, the findings could be valuable for the development of new strategies for effective preservation of solid organs prior to transplantation. ; Scientific and Technological Research Council of Turkey (TUBITAK) [110S103] ; This study was financed by The Scientific and Technological Research Council of Turkey (TUBITAK), project number 110S103. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1570-1646 1875-6247 |
| العلاقة: | Current Proteomics; info:eu-repo/grantAgreement/TUBITAK/SOBAG/110S103; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Coşkun, A., Baykal, A. T., Öztuğ, M., Kazan, D., Kaya, E., Emiroğlu, R. … Yazıcı, C. (2019). Proteomic analysis of liver preservation solutions prior to liver transplantation. Current Proteomics, 16(2), 119-135. https://dx.doi.org/10.2174/1570164615666180905104543Test; https://dx.doi.org/10.2174/1570164615666180905104543Test; https://hdl.handle.net/20.500.12511/1789Test; 16; 119; 135; Q4 |
| DOI: | 10.2174/1570164615666180905104543 |
| الإتاحة: | https://doi.org/20.500.12511/1789Test https://doi.org/10.2174/1570164615666180905104543Test https://hdl.handle.net/20.500.12511/1789Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.6D568009 |
| قاعدة البيانات: | BASE |
| تدمد: | 15701646 18756247 |
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| DOI: | 10.2174/1570164615666180905104543 |