دورية أكاديمية
Cervico-medullary compression ratio: A novel radiological parameter correlating with clinical severity in Chiari type 1 malformation
| العنوان: | Cervico-medullary compression ratio: A novel radiological parameter correlating with clinical severity in Chiari type 1 malformation |
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| المؤلفون: | Doruk, Ebru, Ozay, Rafet, Şekerci, Zeki, Durmaz, Hasan Ali, Güneş, Serra Özbal, Hanalıoğlu, Şahin, Sorar, Mehmet |
| بيانات النشر: | Elsevier Science Bv |
| سنة النشر: | 2018 |
| المجموعة: | İstanbul Medipol University Institutional Repository (DSpace@Medipol) |
| مصطلحات موضوعية: | Chiari Malformation, Herniated Cerebellar Tonsil, Foramen Magnum, Cervico-Medullary Compression Ratio, Syringomyelia, Hydrocephalus |
| الوصف: | WOS: 000450134600021 ; PubMed ID: 30236638 ; Objectives: Chiari malformation type 1 (CM-1) is associated with cough headache, intracranial hypertension, cerebellar and spinal cord symptoms/signs. Herniated cerebellar tonsil length (HCTL) is widely used radiological parameter to determine the severity of CM-1, but with limited utility due to its weak correlation with some clinico-radiological findings. In this study, we aimed to evaluate a novel, practical parameter (cervico-medullary compression ratio; "CMCR") for its relationship with clinico-radiological findings in CM-1. Patients and methods: Thirty-five adult patients (17 F, 18 M) with CM-1 were included in this retrospective study. Head CT and craniospinal MR images were assessed. CMCR was calculated as the ratio of herniated cerebellar tonsil surface area to foramen magnum surface area, and HCTL was measured. These two parameters were correlated with clinical and radiological findings. Results: The mean CMCR was 0.60 +/- 0.15 and mean HCTL was 8.91 +/- 3.4 mm with no significant difference between gender and age groups for both parameters. For cough headache (0.64 +/- 0.14 vs 0.52 +/- 0.15, p = 0.043) and syringomyelia (0.67 +/- 0.11 vs 0.56 +/- 0.16, p = 0.039), only CMCR; for intracranial hypertension (CMCR: 0.64 +/- 0.14 vs 0.55 +/- 0.16, p = 0.049; HCTL: 9.66 +/- 3.59 mm vs 7.79 +/- 3.03 mm; p = 0.045) and cerebellar symptoms (CMCR: 0.65 +/- 0.14 vs 0.54 +/- 0.16, p = 0.048; HCTL: 10.4 +/- 3.5 mm vs 7.4 +/- 2.8 mm, p = 0.041), both CMCR and HTCL were significantly different between patients with and without respective findings. However, neither CMCR nor HTCL was different between patients with and without spinal cord symptoms and hydrocephalus. Conclusion: CMCR is a superior numerical parameter than HCTL for the assessment of clinical severity in CM-1 cases and needs further validation with larger studies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0303-8467 1872-6968 |
| العلاقة: | Clinical Neurology and Neurosurgery; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Doruk, E., Ozay, R., Şekerci, Z., Durmaz, H. A., Güneş, S. Ö., Hanalıoğlu, Ş. . Sorar, M. (2018). Cervico-medullary compression ratio: A novel radiological parameter correlating with clinical severity in Chiari type 1 malformation, 174, 123-128. https://dx.doi.org/10.1016/j.clineuro.2018.09.016Test; https://dx.doi.org/10.1016/j.clineuro.2018.09.016Test; https://hdl.handle.net/20.500.12511/1857Test; 174; 123; 128; Q3; Q2 |
| DOI: | 10.1016/j.clineuro.2018.09.016 |
| الإتاحة: | https://doi.org/20.500.12511/1857Test https://doi.org/10.1016/j.clineuro.2018.09.016Test https://hdl.handle.net/20.500.12511/1857Test |
| حقوق: | info:eu-repo/semantics/embargoedAccess |
| رقم الانضمام: | edsbas.341C947E |
| قاعدة البيانات: | BASE |
| تدمد: | 03038467 18726968 |
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| DOI: | 10.1016/j.clineuro.2018.09.016 |