دورية أكاديمية
Real-world efficacy and safety of Ledipasvir plus Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir +/- Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience
| العنوان: | Real-world efficacy and safety of Ledipasvir plus Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir +/- Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience |
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| المؤلفون: | Değertekin, Bülent, Demir, Mehmet, Akarca, Ulus S., Kani, Haluk Tarık, Üçbilek, Enver, Yıldırım, Emre, Güzelbulut, Fatih, Balkan, Ayhan, Vatansever, Sezgin, Danış, Nilay, Demircan, Melek, Soylu, Aliye, Yaraş, Serkan, Kartal, Aysun, Kefeli, Ayşe, Gündüz, Feyza, Yalçın, Kendal, Erarslan, Elife, Aladağ, Murat, Harputluoğlu, Murat, Özakyol, Ayşegül, Temel, Tuncer, Akarsu, Mesut, Sümer, Hale, Akın, Mete, Albayrak, Bülent, Şen, İlker, Alkım, Hüseyin, Uyanıkoğlu, Ahmet, Irak, Kader, Öztaşkın, Sinem, Uğurlu, Çağrı Burak, Güneş, Şevkican, Gürel, Selim, Nuriyev, Kenan, İnci, İsmail, Kaçar, Sabite, Dinçer, Dinç, Doganay, Levent, Göktürk, Hüseyin Savaş, Mert, Ali, Coşar, Arif Mansur, Dursun, Hakan, Atalay, Roni, Akbulut, Sabiye, Balkan, Yasemin, Köklü, Hayrettin, Şimşek, Halis, Özdoğan, Osman, Çoban, Mehmet, Poturoğlu, Şule, Ayyıldız, Talat, Yapalı, Suna, Günşar, Fulya, Akdoğan, Meral, Özenirler, Seren, Akyıldız, Murat, Sezgin, Orhan, Kaymakoğlu, Sabahattin, Beşışık, Fatih, Karasu, Zeki, İdilman, Ramazan |
| بيانات النشر: | AVES |
| سنة النشر: | 2020 |
| المجموعة: | İstanbul Medipol University Institutional Repository (DSpace@Medipol) |
| مصطلحات موضوعية: | HCV, Treatment, Direct-Acting Antiviral, Turkey |
| الوصف: | Background/Aims: This study aimed to evaluate the real-life efficacy and tolerability of direct-acting antiviral treatments for patients with chronic hepatitis C (CHC) with/without cirrhosis in the Turkish population.Material and Methods: A total of 4,352 patients with CHC from 36 different institutions in Turkey were enrolled. They received ledipasvir (LDV) and sofosbuvir (SOF)+/- ribavirin (RBV) ombitasvir/paritaprevir/ritonavir +/- dasabuvir (PrOD)+/- RBV for 12 or 24 weeks. Sustained virologic response (SVR) rates, factors affecting SVR, safety profile, and hepatocellular cancer (HCC) occurrence were analyzed.Results: SVR12 was achieved in 92.8% of the patients (4,040/4,352) according to intention-to-treat and in 98.3% of the patients (4,040/4,108) according to per-protocol analysis. The SVR12 rates were similar between the treatment regimens (97.2%-100%) and genotypes (95.6%-100%). Patients achieving SVR showed a significant decrease in the mean serum alanine transaminase (ALT) levels (50.90 +/- 54.60 U/L to 17.00 +/- 14.50 U/L) and model for end-stage liver disease (MELD) scores (7.51 +/- 4.54 to 7.32 +/- 3.40) (p<0.05). Of the patients, 2 were diagnosed with HCC during the treatment and 14 were diagnosed with HCC 37.0 +/- 16.0 weeks post-treatment. Higher initial MELD score (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.22-2.38; p=0.023]), higher hepatitis C virus (HCV) RNA levels (OR: 1.44, 95% CI: 1.31-2.28; p=0.038), and higher serum ALT levels (OR: 1.38, 95% CI: 1.21-1.83; p=0.042) were associated with poor SVR12. The most common adverse events were fatigue (12.6%), pruritis (7.3%), increased serum ALT (4.7%) and bilirubin (3.8%) levels, and anemia (3.1%).Conclusion: LDV/SOF or PrOD +/- RBV were effective and tolerable treatments for patients with CHC and with or without advanced liver disease before and after liver transplantation. Although HCV eradication improves the liver function, there is a risk of developing HCC. ; Turkish Association for the Study of The Liver (TASL) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1300-4948 2148-5607 |
| العلاقة: | Turkish Journal of Gastroenterology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Değertekin, B., Demir, M., Akarca, U. S., Kani, H. T., Üçbilek, E., Yıldırım, E. . İdilman, R. (2020). Real-world efficacy and safety of Ledipasvir plus Sofosbuvir and Ombitasvir/Paritaprevir/Ritonavir +/- Dasabuvir combination therapies for chronic hepatitis C: A Turkish experience. Turkish Journal of Gastroenterology, 31(12), 883-893. https://dx.doi.org/10.5152/tjg.2020.20696Test; https://dx.doi.org/10.5152/tjg.2020.20696Test; https://hdl.handle.net/20.500.12511/6598Test; 31; 12; 883; 893; Q4; Q3 |
| DOI: | 10.5152/tjg.2020.20696 |
| الإتاحة: | https://doi.org/20.500.12511/6598Test https://doi.org/10.5152/tjg.2020.20696Test https://hdl.handle.net/20.500.12511/6598Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9D196D09 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13004948 21485607 |
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| DOI: | 10.5152/tjg.2020.20696 |