دورية أكاديمية
Predictive models for tuberculous pleural effusions in a high tuberculosis prevalence region
| العنوان: | Predictive models for tuberculous pleural effusions in a high tuberculosis prevalence region |
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| المؤلفون: | Demirer, Ersin, Miller, Andrew Cate, Kunter, Erdoğan, Kartaloǧlu, Zafer, Barnett, Scott D., Elamin, Elamin M. |
| بيانات النشر: | Springer |
| سنة النشر: | 2012 |
| المجموعة: | İstanbul Medipol University Institutional Repository (DSpace@Medipol) |
| مصطلحات موضوعية: | Adenosine Deaminase Enzyme, Lactate Dehydrogenase Enzyme, Pulmonary Tuberculosis, Tuberculous Pleural Effusion |
| الوصف: | WOS: 000302146900015 ; PubMed ID: 22057296 ; Patients with pleural effusions who reside in geographic areas with a high prevalence of tuberculosis frequently have similar clinical manifestations of other diseases. The aim of our study was to develop a simple but accurate clinical score for differential diagnosis of tuberculosis pleural effusion (TPE) from non-TB pleural effusion (NTPE). This was an unblinded, prospective study of Turkish patients 18 years of age or older with pleural effusion of indeterminate etiology conducted from June 2003 to June 2005. Unconditional logistic regression models were used to discriminate TPE cases from NTPE cases. Standard errors for the area under the curve (AUC) were calculated using the Mann-Whitney method. Data were statistically significance if two-tailed P < 0.05. A total of 63.3% (157/248) of the patients had TPE while 36.7% (91/248) of the patients had other etiologies for pleural effusions. We were able to provide a predictive model of TPE that included age < 47 years and either pleural fluid adenosine deaminase enzyme (PADA) > 35 U/l or pleural serum protein ratio > 0.710. However, only the combination of age < 47 and PADA > 35 U/l was significant (odds ratio [OR]: 7.46; 95% confidence interval [CI]: 3.99-13.96). The generated summary score (range = 0-6) was significantly predictive of TPE (OR: 2.91; 95% CI: 2.18-3.89) and with high AUC (0.79). We propose an affordable model that includes age < 47 years and PADA > 35 U/l for timely diagnosis of TPE in geographical regions with a high prevalence of TB. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0341-2040 1432-1750 |
| العلاقة: | Lung; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Demirer, E., Miller, A. C., Kunter, E., Kartaloǧlu, Z., Barnett, S. D. ve Elamin, E. M. (2012). Predictive models for tuberculous pleural effusions in a high tuberculosis prevalence region. Lung, 190(2), 239-248. https://dx.doi.org/10.1007/s00408-011-9342-zTest; https://dx.doi.org/10.1007/s00408-011-9342-zTest; https://hdl.handle.net/20.500.12511/3392Test; 190; 239; 248; Q3; Q2 |
| DOI: | 10.1007/s00408-011-9342-z |
| الإتاحة: | https://doi.org/20.500.12511/3392Test https://doi.org/10.1007/s00408-011-9342-zTest https://hdl.handle.net/20.500.12511/3392Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4E9F0897 |
| قاعدة البيانات: | BASE |
| تدمد: | 03412040 14321750 |
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| DOI: | 10.1007/s00408-011-9342-z |