دورية أكاديمية
Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans
| العنوان: | Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans |
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| المؤلفون: | Chauve, Laetitia, Hodge, Francesca, Murdoch, Sharlene, Masoudzadeh, Fatemah, Mann, Harry-Jack, Lopez-Clavijo, Andrea, Okkenhaug, Hanneke, West, Greg, Sousa, Bebiana C., Segonds-Pichon, Anne, Li, Cheryl, Wingett, Steven, Kienberger, Hermine, Kleigrewe, Karin, de Bono, Mario, Wakelam, Michael, Casanueva, Olivia |
| المصدر: | Chauve L, Hodge F, Murdoch S, et al. Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans. 2021. doi: 10.5281/ZENODO.5519410 |
| بيانات النشر: | Zenodo |
| سنة النشر: | 2021 |
| المجموعة: | IST Austria Research Explorer (Institute of Science and Technology) |
| مصطلحات موضوعية: | ddc:570 |
| الوصف: | To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell-autonomous. We have discovered that, in Caenorhabditis elegans, neuronal Heat shock Factor 1 (HSF-1), the conserved master regulator of the heat shock response (HSR)- causes extensive fat remodelling in peripheral tissues. These changes include a decrease in fat desaturase and acid lipase expression in the intestine, and a global shift in the saturation levels of plasma membrane’s phospholipids. The observed remodelling of plasma membrane is in line with ectothermic adaptive responses and gives worms a cumulative advantage to warm temperatures. We have determined that at least six TAX-2/TAX-4 cGMP gated channel expressing sensory neurons and TGF-β/BMP are required for signalling across tissues to modulate fat desaturation. We also find neuronal hsf-1 is not only sufficient but also partially necessary to control the fat remodelling response and for survival at warm temperatures. This is the first study to show that a thermostat-based mechanism can cell non-autonomously coordinate membrane saturation and composition across tissues in a multicellular animal. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://research-explorer.ista.ac.at/record/13069Test |
| الإتاحة: | https://doi.org/10.5281/ZENODO.5519410Test https://research-explorer.ista.ac.at/record/13069Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F2CB7E49 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |