دورية أكاديمية
Communication between human mast cells and CD4^{+}$ T cells through antigen-dependent interactions
| العنوان: | Communication between human mast cells and CD4^{+}$ T cells through antigen-dependent interactions |
|---|---|
| المؤلفون: | Suurmond, Jolien, van Heemst, Jurgen, van Heiningen, Jacqueline, Dorjee, Annemarie L., Schilham, Marco W., van der Beek, Feddo B., Huizinga, Tom W. J., Schuerwegh, Annemie, Toes, René E.M. |
| المصدر: | 0014-2980 ; European journal of immunology |
| سنة النشر: | 2013 |
| المجموعة: | IRUA - Institutional Repository van de Universiteit Antwerpen |
| مصطلحات موضوعية: | Human medicine |
| الوصف: | Mast cells (MCs) are immune cells residing in tissues where pathogens are first encountered. It has been indicated that MCs might also be involved in setting the outcome of T-cell responses. However, little is known about the capacity of human MCs to express MHC class II and/or to capture and present antigens to CD4(+) T cells. To study the T-cell stimulatory potential of human MCs, CD34(+) stem cell derived MCs were generated. These cells expressed HLA-DR when stimulated with IFN-, and, importantly, presented peptide and protein for activation of antigen-specific CD4(+) T cells. The interplay between MC and T cell led to increased HLA-DR expression on MCs. MCs were present in close proximity to T cells in tonsil and expressed HLA-DR and CD80, indicating their ability to present antigens to CD4(+) T cells in T-cell areas of human LNs. Our data show that MCs can present native antigens to human CD4(+) T cells and that HLA-DR expressing MCs are present in tonsil tissue, indicating that human MCs can directly activate T cells and provide a rationale to study the potential of MCs to prime and/or skew human T-cell responses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/isi/000327695500011 |
| الإتاحة: | https://doi.org/10.1002/EJI.201243058Test https://hdl.handle.net/10067/1127840151162165141Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.CEE18B12 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |