دورية أكاديمية
Effect of amoxicillin dose and treatment duration on the need for antibiotic re-treatment in children with community-acquired pneumonia : the CAP-IT randomized clinical trial
| العنوان: | Effect of amoxicillin dose and treatment duration on the need for antibiotic re-treatment in children with community-acquired pneumonia : the CAP-IT randomized clinical trial |
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| المؤلفون: | Bielicki, Julia A., Stöhr, Wolfgang, Barratt, Sam, Dunn, David, Naufal, Nishdha, Roland, Damian, Sturgeon, Kate, Finn, Adam, Rodriguez Ruiz, Juan Pablo, Malhotra, Surbhi, Powell, Colin, Faust, Saul N., Alcock, Anastasia E., Hall, Dani, Robinson, Gisela, Hawcutt, Daniel B., Lyttle, Mark D., Gibb, Diana M., Sharland, Mike, Molyneux, Elizabeth, Butler, Chris C., Smyth, Alan, Prichard, Catherine, Peto, Tim E.A., Cousens, Simon, Logan, Stuart, Bamford, Alasdair, Turkova, Anna, Goodman, Anna L., Fitzgerald, Felicity, Little, Paul S., Robotham, Julie, Wan, Mandy, Klein, Nigel, Rogers, Louise, Vitale, Elia, Rotheram, Matthew, Wright, Rachel, Lee, Elizabeth, Ohia, Udeme, Hartshorn, Stuart, Jyothish, Deepthi, Hopkins, Juliet, Ross, James G., Patel, Poonam, Fletcher, Hannah, Nundlall, Kribashnie, Carungcong, Jamie, Bull, Rhian, Burney, Nabila, Correia Da Costa, Patricia, Vergnano, Stefania, Walton, Beth, Smith, Alice, Ross, Michelle, Aplin, Lucie, Sheedy, Sarah, Kaur, Gurnie, Morgan, Jeff, Muller, Jennifer, Marshall, Gail, Nyamugunduru, Godfrey, Furness, John C., Eggington, Dawn, Holt, Susannah J., Gibbs, John, Burchett, Caroline, Lonsdale, Caroline, De-Beger, Sarah, Cheung, Ronny, Sheedy, Alyce B., Ahmad, Mohammad, Stockwell, Zoe, Giwa, Sarah, Murad, Arshid, Jerman, Katherine, Green, Joanna, Bird, Chris, Baron, Tanya K. Z., Segal, Shelley, Beer, Sally, Garcia Garcia, Maria Jose, Georgiou, Dom, Beadon, Kirsten, Martinez, Jose, Cantle, Fleur, Eastman, Hannah, Riozzi, Paul, Cotton, Hannah, Mullen, Niall, McCrone, Rhona, Corrigan, Paul, Salt, Gemma, Fairlie, Louise, Smith, Andrew, Starkey, Lizzie, Hayman, Mel, O'Riordan, Sean, Downes, Alice, Allen, Majorie, Turner, Louise, Ellis, Donna, Bandi, Srini, Patel, Rekha, Gough, Chris, McAulay, Megan, Conner, Louise, Gardner, Sharryn, Haslam, Zena, Morrison, Moira, Barrett, Michael J., Niermeyer, Madeleine, Barry, Ellen, Walton, Emily K., Kapur, Akshat, Richmond, Vivien, Foster, Steven J., Bland, R.M., Neil, Ashleigh, Milligan, Barry, Bannister, Helen, Bloom, Ben, Parikh, Ami, Skene, Imogen, Power, Helen, Boulton, Olivia, Astin-Chamberlain, Raine, Smith, David, Walters, Jonathon, Martin, Daniel, Noba, Lyrics, Potier, Katherine, Borland, Fiona, Wilson, Jill, Suleman, Zainab, Gilchrist, Judith, West, Noreen, Evans, Jayne, Morecombe, Juliet, Heath, Paul T., Iqbal, Yasser, Kohns Vasconcelos, Malte, Stefanova, Elena, Womack, Claire, Maconochie, Ian K., Laing, Suzanne, Jorgensen, Rikke, Nyirenda, Maggie, Keers, Sophie, Pilgrim, Samia, Gardiner, Emma, Cathie, Katrina, Bayreuther, Jane, Ensom, Ruth, Cornish, Emily K., Herrieven, Elizabeth-Jayne L., Townend, William, Sherris, Leanne, Williams, Paul |
| المصدر: | 0098-7484 ; JAMA : the journal of the American Medical Association |
| سنة النشر: | 2021 |
| المجموعة: | IRUA - Institutional Repository van de Universiteit Antwerpen |
| مصطلحات موضوعية: | Pharmacology. Therapy, Human medicine |
| الوصف: | This randomized clinical trial compares the need for re-treatment of respiratory infection following hospitalization for community-acquired pneumonia among children receiving amoxicillin at high doses vs low doses and at 3-days vs 7-days duration. Question For children with community-acquired pneumonia discharged from an emergency department, observational unit, or inpatient ward (within 48 hours), is subsequent outpatient treatment with oral amoxicillin at a dose of 35 to 50 mg/kg per day noninferior to 70 to 90 mg/kg per day, and is a 3-day course noninferior to 7 days, with regard to the need for antibiotic re-treatment? Findings In this 2 x 2 factorial randomized clinical trial of 814 children requiring amoxicillin for community-acquired pneumonia at hospital discharge, antibiotic re-treatment within 28 days occurred in 12.6% vs 12.4% of those randomized to lower vs higher doses, and in 12.5% vs 12.5% of those randomized to 3-day vs 7-day amoxicillin duration. Both comparisons met the prespecified 8% noninferiority margin. Meaning Among children with community-acquired pneumonia discharged from an emergency department, observational unit, or inpatient ward, further outpatient treatment with oral amoxicillin at a dose of 35 to 50 mg/kg per day was noninferior to a dose of 70 to 90 mg/kg per day and 3 days was noninferior to 7 days with regard to the need for later antibiotic re-treatment. Importance The optimal dose and duration of oral amoxicillin for children with community-acquired pneumonia (CAP) are unclear. Objective To determine whether lower-dose amoxicillin is noninferior to higher dose and whether 3-day treatment is noninferior to 7 days. Design, Setting, and Participants Multicenter, randomized, 2 x 2 factorial noninferiority trial enrolling 824 children, aged 6 months and older, with clinically diagnosed CAP, treated with amoxicillin on discharge from emergency departments and inpatient wards of 28 hospitals in the UK and 1 in Ireland between February 2017 and April 2019, with last trial ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/isi/000718138900020 |
| الإتاحة: | https://doi.org/10.1001/JAMA.2021.17843Test https://hdl.handle.net/10067/1835300151162165141Test https://repository.uantwerpen.be/docstore/d:irua:9492Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9C5047BA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |