دورية أكاديمية
CSF monoamine metabolites in old age dementias.
| العنوان: | CSF monoamine metabolites in old age dementias. |
|---|---|
| المؤلفون: | PARNETTI, Lucilla, A. Gaiti, REBOLDI, Gianpaolo, C. Santucci, MECOCCI, Patrizia, M. Brunetti, D. Cadini, SENIN, Umberto |
| المساهمون: | Parnetti, Lucilla, Gaiti, A., Reboldi, Gianpaolo, Santucci, C., Mecocci, Patrizia, Brunetti, M., Cadini, D., Senin, Umberto |
| سنة النشر: | 1992 |
| المجموعة: | IRIS Università degli Studi di Perugia |
| مصطلحات موضوعية: | Aged, 80 and over, Alzheimer Disease, cerebrospinal fluid, Dementia, Vascular, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Intervertebral Disc Displacement, Methoxyhydroxyphenylglycol, Middle Aged, Psychological Tests |
| الوصف: | Cerebrospinal Fluid (CSF) levels of the main metabolites of monoamines (MHPG, 5-HIAA, and HVA) were measured in patients with early onset (AD) and late-onset (SDAT) Alzheimer's disease, vascular dementia (VD), and elderly controls. Psychobehavioral assessment was carried out by means of MMSE and GBS. Mean MHPG levels did not differ from controls; 5-HIAA was lower in VD when compared to both controls and SDAT. HVA was decreased in AD, SDAT, and VD with respect to controls. Significant correlations between HVA and psycho-behavioral parameters were observed in SDAT and VD groups, whereas no relationship was documented in AD. The SDAT group was divided in SDAT-A (age at onset: greater than 65 less than or equal to 80 yr) and SDAT-B (age at onset: greater than 80 yr). SDAT-A had significantly lower CSF HVA values than SDAT-B (165 +/- 64 vs 235.7 +/- 85). SDAT-B HVA levels were similar to those observed in controls. Correlation analysis between HVA and neuropsychological variables was significant in SDAT-A, but not in SDAT-B. These results might support the evidence of SDAT heterogeneity. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/1381590; info:eu-repo/semantics/altIdentifier/wos/WOS:A1992HQ51500011; volume:16; firstpage:143; lastpage:157; numberofpages:14; journal:MOLECULAR AND CHEMICAL NEUROPATHOLOGY; http://hdl.handle.net/11391/1038951Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0026726539; http://www.ncbi.nlm.nih.gov/pubmed/?term=1381590Test |
| DOI: | 10.1007/BF03159966 |
| الإتاحة: | https://doi.org/10.1007/BF03159966Test http://hdl.handle.net/11391/1038951Test http://www.ncbi.nlm.nih.gov/pubmed/?term=1381590Test |
| رقم الانضمام: | edsbas.540FEFF2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/BF03159966 |
|---|