Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

التفاصيل البيبلوغرافية
العنوان:	Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index
المؤلفون:	Hinney, Anke, Kesselmeier, M., Jall, S., Volckmar, A. -L., Föcker, M., Antel, J., Heid, I. M., Winkler, T. W., Grant, S. F. A., Guo, Yiran, Bergen, A. W., Kaye, Walter, Berrettini, Wade, Hakonarson, H., Herpertz-Dahlmann, Beate, de Zwaan, Martina, Herzog, Wolfgang, Ehrlich, Stefan, Zipfel, Stephan, Egberts, Karin, Adan, Roger A. H., Brandys, Marek K, van Elburg, Annemarie A, Boraska Perica, V., Franklin, Christopher S., Tschöp, M. H., Zeggini, Eleftheria, Bulik, Cynthia M, Collier, David A, Scherag, A., Hebebrand, Johannes, Perica, Vesna Boraska, Floyd, James A. B., Thornton, Laura M., Huckins, Laura M, Southam, Lorraine, Rayner, N. William, Tachmazidou, Ioanna, Klump, Kelly L, Treasure, Janet, Lewis, Cathryn M., Schmidt, Ulrike, Tozzi, Federica, Iezebrink, Kirsty, Gorwood, Philip, Kas, Martien J. H, Favaro, Angela, Santonastaso, Paolo, Fernández-Aranda, Fernando, Gratacos, Monica, Rybakowski, Filip, Dmitrzak-Weglarz, Monika, Kaprio, Jaakko, Keski-Rahkonen, Anna, Raevuori-Helkamaa, Anu, Van Furth, Eric F., Slof-Op’t Landt, Margarita C. T., Hudson, James I, Reichborn-Kjennerud, Ted, Knudsen, Gun Peggy S., Monteleone, Palmiero, Kaplan, A. S., Karwautz, Andreas, Li, Dong, Komaki, Gen, Ando, Tetsuya, Inoko, Hidetoshi, Esko, Tõnu, Fischer, Krista, Männik, Katrin, Metspalu, Andres, Schork, Nicholas J, Cone, Roger D, Dackor, Jennifer, DeSocio, Janiece E, Hilliard, Christopher E, O’Toole, Julie K, Pantel, Jacques, Szatkiewicz, Jin P, Taico, Chrysecolla, Zerwas, Stephanie, Trace, Sara E, Davis, Oliver S. P., Helder, Sietske, Bühren, Katharina, Burghardt, Roland, Imgart, Hartmut, Scherag, Susann, Boni, Claudette, Ramoz, Nicolas, Versini, Audrey, Danner, Unna N, de Kove, Carolien, Hendriks, Judith, Koeleman, Bobby P. C., Ophoff, Roel A, Strengman, Eric, Bruson, Alice, Clementi, Maurizio, Degortes, Daniela, Forzan, Monica, Tenconi, Elena, Docampo, Elisa, Jiménez-Murcia, Geòrgia Escaramí Susana, Lissowska, Jolanta, Rajewski, Andrzej, Szeszenia-Dabrowska, Neonila, Slopien, Agnieszka, Hauser, Joanna, Karhunen, Leila, Meulenbelt, Ingrid, Slagboom, P Eline, Tortorella, Alfonso, Maj, Mario, Dedoussis, George, Dedoussis, G. V., Dikeos, Dimitris, Gonidakis, Fragiskos, Tziouvas, Konstantinos, Tsitsika, Artemis, Papezova, Hana, Slachtova, Lenka, Martaskova, Debora, Kennedy, James L, Levitan, Robert D, Yilmaz, Zeynep, Huemer, Julia, Koubek, Doris, Merl, Elisabeth, Wagner, Gudrun, Lichtenstein, Paul, Breen, Gerome, Cohen-Woods, Sarah, Farmer, Anne, McGuffin, Peter, Cichon, Sven, Giegling, Ina, Herms, Stefan, Rujescu, Dan, Schreiber, Stefan, Wichmann, H. E., Christian, Dina, Sladek, Rob, Gambaro, Giovanni, Soranzo, N., Julia, Antonio, Marsal, Sara, Rabionet, Raquel, Gaborieau, Valerie, Dick, Danielle M, Palotie, Aarno, Ripatti, Samuli, Widén, E., Andreassen, Ole A, Espeseth, Thomas, Lundervold, Astri, Reinvang, Ivar, Steen, Vidar M, Le Hellard, Stephanie, Mattingsdal, Morten, Ntalla, I., Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Navratilova, Marie, Gallinger, Steven, Pinto, Dalila, Scherer, Stephen W, Aschauer, Harald, Carlberg, Laura, Schosser, Alexandra, Alfredsson, Lars, Ding, Bo, Klareskog, Lars, Padyukov, Leonid, Finan, Chris, Kalsi, Gursharan, Roberts, Marion, Logan, Darren W, Peltonen, Leena, Ritchie, Graham R. S., Barrett, Jeff C, Estivill, X., Sullivan, Patrick F, Anderson, Carl A, McGinnis, Ralph, Sambrook, Jennifer, Stephens, Jonathan, Ouwehand, Willem H, McArdle, W. L., Ring, S. M., Strachan, D. P., Alexander, Graeme, Conlon, Peter J, Dominiczak, Anna, Duncanson, Audrey, Hill, Adrian, Langford, Cordelia, Lord, Graham, Maxwell, Alexander P, Morgan, Linda, Sandford, Richard N, Sheerin, Neil, Vannberg, Frederik O, Blackburn, H., Chen, W., Edkins, Sarah, Gillman, Mathew, Gray, Emma, Hunt, Sarah E, Nengut, Suna-Gumuscu, Potter, Simon, Rich, Stephen S, Simpkin, Douglas, Whittaker, Pamela, Adair, L. S., Ang, W., Atalay, M., van Beijsterveldt, T., Bergen, N., Benke, K., Berry, D. J., Boomsma, D. I., Bradfield, J. P., Charoen, P., Coin, L., Cooper, C., Cousminer, D. L., Das, S., Elliott, P., Evans, D. M., Feenstra, B., Flexeder, C., Frayling, T., Freathy, R. M., Gaillard, R., Geller, F., Groen-Blokhuis, M., Goh, L. K., Guxens, M., Hattersley, A. T., Haworth, C. M., Hadley, D., Heinrich, J., Hirschhorn, J. N., Hocher, B., Holloway, J. W., Holst, C., Hottenga, J. J., Horikoshi, M., Huikari, V., Hypponen, E., Iñiguez, C., Jaddoe, V. W., Jarvelin, M. R., Kaakinen, M., Kilpeläinen, T. O., Kirin, M., Kowgier, M., Lakka, H. M., Lakka, T. A., Lange, L. A., Lawlor, D. A., Lehtimäki, T., Lewin, A., Lindgren, C., Lindi, V., Maggi, R., Marsh, J., McCarthy, M. I., Melbye, M., Middeldorp, C., Millwood, I., Mohlke, K. L., Mook-Kanamori, D. O., Murray, J. C., Nivard, M., Nohr, E. A., Oken, E., Ong, K. K., O'Reilly, P. F., Palmer, L. J., Panoutsopoulou, K., Pararajasingham, J., Pearson, E. R., Pennell, C. E., Power, C., Price, T. S., Prokopenko, I., Raitakari, O. T., Rodriguez, A., Salem, R. M., Saw, S. M., Sebert, S., Siitonen, N., Simell, O., Sørensen, T. I., Sovio, U., Pourcain, B. S., Sunyer, J., Taal, H. R., Teo, Y. Y., Thiering, E., Tiesler, C., Timpson, N. J., Uitterlinden, A. G., Valcárcel, B., Warrington, N. M., White, S., Willemsen, G., Wilson, J. F., Yaghootkar, H., Elks, C. E., Perry, J. R., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Gudbjartsson, D. F., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., Smith, A. V., Stolk, L., van Wingerden, S. H., Zhao, J. H., Albrecht, E., Corre, T., Ingelsson, E., Hayward, C., Magnusson, P. K., Smith, E. N., Ulivi, S., Warrington, M., Zgaga, L., Alavere, H., Amin, N., Aspelund, T., Bandinelli, S., Barroso, I., Berenson, G. S., Bergmann, S., Boerwinkle, E., Buring, J. E., Busonero, F., Campbell, H., Chanock, S. J., Cornelis, M. C., Couper, D., Coviello, A. D., d'Adamo, P., de Faire, U., de Geus, E. J., Deloukas, P., Döring, A., Davey Smith, G., Easton, D. F., Eiriksdottir, G., Emilsson, V., Eriksson, J., Ferrucci, L., Folsom, A. R., Foroud, T., Garcia, M., Gasparini, P., Gieger, C., Gudnason, V., Hall, P., Hankinson, S. E., Ferreli, L., Heath, A. C., Hernandez, D. G., Hofman, A., Hu, F. B., Illig, T., Järvelin, M. R., Johnson, A. D., Karasik, D., Khaw, K. T., Kiel, D. P., Kolcic, I., Kraft, P., Launer, L. J., Laven, J. S., Li, S., Liu, J., Levy, D., Martin, N. G., Mooser, V., Murray, S. S., Nalls, M. A., Navarro, P., Nelis, M., Ness, A. R., Northstone, K., Oostra, B. A., Peacock, M., Paré, G., Parker, A. N., Pedersen, N. L., Pharoah, P., Polasek, O., Plump, A. S., Pouta, A., Porcu, E., Rafnar, T., Rice, J. P., Rivadeneira, F., Rudan, I., Sala, C., Salomaa, V., Sanna, S., Schlessinger, D., Scuteri, A., Segrè, A. V., Shuldiner, A. R., Srinivasan, S. R., Tammesoo, M. L., Tikkanen, E., Toniolo, D., Tsui, K., Tryggvadottir, L., Tyrer, J., Uda, M., van Dam, R. M., van Meurs, J. B., Vollenweider, P., Waeber, G., Wareham, N. J., Waterworth, D. M., Weedon, M. N., Wright, A. F., Young, L., Zhai, G., Zhuang, W. V., Bierut, L. J., Boyd, H. A., Crisponi, L., Demerath, E. W., van Duijn, C. M., Econs, M. J., Harris, T. B., Hunter, D. J., Loos, R. J., Ridker, P. M., Spector, T. D., Streeten, E. A., Stefansson, K., Thorsteinsdottir, U., Widen, E., Murabito, J. M., Murray, A., Brandt, Harry, Crawford, Steve, Crow, Scott, Fichter, M. M., Halmi, K. A., Johnson, Craig, La Via, Maria, Mitchell, James, Strober, Michael, Rotondo, Alessandro, Woodside, D Blake, Keel, Pamela, Lilenfeld, Lisa, Plotnicov, Kathy, Magistretti, Pierre, Montgomery, G. W.
المساهمون:	Hinney, Anke, Kesselmeier, M., Jall, S., Volckmar, A. -L., Föcker, M., Antel, J., Heid, I. M., Winkler, T. W., Grant, S. F. A., Guo, Yiran, Bergen, A. W., Kaye, Walter, Berrettini, Wade, Hakonarson, H., Herpertz-Dahlmann, Beate, de Zwaan, Martina, Herzog, Wolfgang, Ehrlich, Stefan, Zipfel, Stephan, Egberts, Karin, Adan, Roger A. H., Brandys, Marek K, van Elburg, Annemarie A, Boraska Perica, V., Franklin, Christopher S., Tschöp, M. H., Zeggini, Eleftheria, Bulik, Cynthia M, Collier, David A, Scherag, A., Hebebrand, Johanne, Perica, Vesna Boraska, Floyd, James A. B., Thornton, Laura M., Huckins, Laura M, Southam, Lorraine, Rayner, N. William, Tachmazidou, Ioanna, Klump, Kelly L, Treasure, Janet, Lewis, Cathryn M., Schmidt, Ulrike, Tozzi, Federica, Iezebrink, Kirsty, Gorwood, Philip, Kas, Martien J. H, Favaro, Angela, Santonastaso, Paolo, Fernández-Aranda, Fernando, Gratacos, Monica, Rybakowski, Filip, Dmitrzak-Weglarz, Monika, Kaprio, Jaakko, Keski-Rahkonen, Anna, Raevuori-Helkamaa, Anu, Van Furth, Eric F., Slof-Op’t Landt, Margarita C. T., Hudson, James I, Reichborn-Kjennerud, Ted, Knudsen, Gun Peggy S., Monteleone, Palmiero, Kaplan, A. S., Karwautz, Andrea, Li, Dong, Komaki, Gen, Ando, Tetsuya, Inoko, Hidetoshi, Esko, Tõnu, Fischer, Krista, Männik, Katrin, Metspalu, Andre, Schork, Nicholas J, Cone, Roger D, Dackor, Jennifer, Desocio, Janiece E, Hilliard, Christopher E, O’Toole, Julie K, Pantel, Jacque, Szatkiewicz, Jin P, Taico, Chrysecolla, Zerwas, Stephanie, Trace, Sara E, Davis, Oliver S. P., Helder, Sietske, Bühren, Katharina, Burghardt, Roland, Imgart, Hartmut, Scherag, Susann, Boni, Claudette, Ramoz, Nicola, Versini, Audrey, Danner, Unna N, de Kove, Carolien, Hendriks, Judith, Koeleman, Bobby P. C., Ophoff, Roel A, Strengman, Eric, Bruson, Alice, Clementi, Maurizio, Degortes, Daniela
سنة النشر:	2017
المجموعة:	IRIS Università degli Studi di Perugia
مصطلحات موضوعية:	Allele, Anorexia Nervosa, Body Mass Index, Body Weight, Databases, Genetic, Female, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Human, Linkage Disequilibrium, Male, Obesity, Polymorphism, Single Nucleotide, Risk Factor, Molecular Biology, Psychiatry and Mental Health, Cellular and Molecular Neuroscience
الوصف:	The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and viceversa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we erformed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values o 5×10−5, Bonferroni-corrected P o 0.05) for nine SNP alleles at three independent loci. Interestingly, all AN susceptibility alleles were consistently associated with increased BMI. None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2: CARF and NBEAL1; the latter is a region with high linkage disequilibrium) nearest to these SNPs has previously been associated with AN or obesity. Sex-stratified analyses revealed that the strongest BMI signal originated predominantly from females (chr. 10 rs1561589; P overall: 2.47 × 10−06/Pfemales: 3.45 × 10−07/Pmales: 0.043). Functional ex vivo studies in mice revealed reduced hypothalamic expression of Ctbp2 and Nbeal1 after fasting. Hypothalamic expression of Ctbp2 was increased in diet-induced obese (DIO) mice as compared with age-matched lean controls. We observed no evidence for associations for the look-up of BMI-related loci in the AN GWAMA. A cross-trait analysis of AN and BMI loci revealed variants at three chromosomal loci with potential joint impact. The chromosome 10 locus is particularly promising given that the association with obesity was primarily driven by ...
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	STAMPA
اللغة:	English
العلاقة:	info:eu-repo/semantics/altIdentifier/pmid/27184124; info:eu-repo/semantics/altIdentifier/wos/WOS:000394102600007; volume:22; issue:2; firstpage:192; lastpage:201; numberofpages:10; journal:MOLECULAR PSYCHIATRY; http://hdl.handle.net/11391/1431767Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84968552358; http://www.nature.com/mp/index.htmlTest
DOI:	10.1038/mp.2016.71
الإتاحة:	https://doi.org/10.1038/mp.2016.71Test http://hdl.handle.net/11391/1431767Test http://www.nature.com/mp/index.htmlTest
رقم الانضمام:	edsbas.7A463992
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1038/mp.2016.71