دورية أكاديمية
Diagnostic and prognostic value of H-FABP in acute coronary syndrome: Still evidence to bring
| العنوان: | Diagnostic and prognostic value of H-FABP in acute coronary syndrome: Still evidence to bring |
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| المؤلفون: | Bivona, Giulia, Agnello, Luisa, Bellia, Chiara, Lo Sasso, Bruna, Ciaccio, Marcello |
| المساهمون: | Bivona, Giulia, Agnello, Luisa, Bellia, Chiara, Lo Sasso, Bruna, Ciaccio, Marcello |
| بيانات النشر: | Elsevier Inc. |
| سنة النشر: | 2018 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | ACS, AMI, Chest pain, H-FABP, Rule-in, Rule-out, Acute Coronary Syndrome, Animal, Biomarker, Fatty Acid Binding Protein 3, Human, Predictive Value of Test, Troponin C, Clinical Biochemistry |
| الوصف: | The assessment of chest pain patients presenting to the emergency area (EA) is still a clinical challenge, as the majority of patients are not diagnosed with acute coronary syndrome (ACS). New generation high sensitivity c-Tn (hs-cTn) assays have showed better performances compared to the standard c-Tn. However, hs-Tn still presents some limitations. Hence, novel, early biomarkers are needed in this setting. Among all, heart-type fatty acid binding protein (H-FABP) has been largely investigated. This article reviews the studies evaluating H-FABP performance in diagnosing acute myocardial infarction (AMI) and stratifying chest pain patients by risk. H-FABP optimal performances in ACS have been reported by studies that used low threshold for positivity, or compared the biomarker to cTn at 3–6 h, or by studies with small sample size. Literature review allows stating that H-FABP is clearly not a reliable marker in ACS, as it is unable to diagnose AMI, neither as a stand-alone test nor combined with hs-cTn. Few evidence supports its incremental value in ruling-out AMI and its risk stratification ability for chest pain patients presenting to EA. Thus, available data may not encourage going on investigating. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29698621; info:eu-repo/semantics/altIdentifier/wos/WOS:000438388500001; volume:58; firstpage:1; lastpage:4; numberofpages:4; journal:CLINICAL BIOCHEMISTRY; http://hdl.handle.net/10447/347217Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85046167143 |
| DOI: | 10.1016/j.clinbiochem.2018.04.021 |
| الإتاحة: | https://doi.org/10.1016/j.clinbiochem.2018.04.021Test http://hdl.handle.net/10447/347217Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.B6605691 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.clinbiochem.2018.04.021 |
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