التفاصيل البيبلوغرافية
| العنوان: |
Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling. |
| المؤلفون: |
GARLANDA C, VECCHI A, BURACCHI C, MANTOVANI A., DI LIBERTO, Diana, LA MANNA, Marco Pio, CACCAMO, Nadia Rosalia, SALERNO, Alfredo, DIELI, Francesco |
| المساهمون: |
GARLANDA C, DI LIBERTO D, VECCHI A, LA MANNA MP, BURACCHI C, CACCAMO N, SALERNO A, DIELI F, MANTOVANI A |
| سنة النشر: |
2007 |
| المجموعة: |
IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: |
Toll IL-1 Receptor 8/Single Ig IL-1-Related Receptor, Inlfammation, Mycobacterium tuberculosis |
| الوصف: |
Toll IL-1R 8/single Ig IL-1-related receptor (TIR8/SIGIRR) is a member of the IL-1R family, expressed by epithelial tissues and immature dendritic cells, and is regarded as a negative regulator of TLR/IL-1R signaling. Tir8-deficient mice were rapidly killed by intranasal administration of low doses of Mycobacterium tuberculosis, despite controlling efficiently the number of viable bacilli in different organs. Tir8–/–-infected mice showed an increased number of neutrophils and macrophages in the lungs; however, mycobacteria-specific CD4 and CD8 T cells were similar in Tir8–/– and Tir8+/+ mice. Exaggerated mortality of Tir8–/– mice was due to massive liver necrosis and was accompanied by increased levels of IL-1β and TNF-α in lung mononuclear cells and serum, as well as by increased production of IL-1β and TNF-α by M. tuberculosis-infected dendritic cells in vitro. Accordingly, blocking IL-1β and TNF-α with a mix of anti-cytokine Abs, significantly prolonged survival of Tir8–/– mice. Thus, TIR8/SIGIRR plays a key role in damping inflammation and tissue damage in M. tuberculosis infection. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000248991800052; volume:179(5); firstpage:3119; lastpage:3125; journal:JOURNAL OF IMMUNOLOGY; http://hdl.handle.net/10447/3193Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-38449105679 |
| الإتاحة: |
http://hdl.handle.net/10447/3193Test |
| رقم الانضمام: |
edsbas.47B5AAE8 |
| قاعدة البيانات: |
BASE |
