دورية أكاديمية
BRAF mutations in non-small cell lung cancer: Has finally Janus opened the door?
| العنوان: | BRAF mutations in non-small cell lung cancer: Has finally Janus opened the door? |
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| المؤلفون: | Caparica, Rafael, de Castro, Gilberto, Gil-Bazo, Ignacio, Caglevic, Christian, Calogero, Raffaele, Giallombardo, Marco, Santos, Edgardo S., Raez, Luis E., Rolfo, Christian |
| المساهمون: | Caparica, Rafael, de Castro, Gilberto, Gil-Bazo, Ignacio, Caglevic, Christian, Calogero, Raffaele, Giallombardo, Marco, Santos, Edgardo S., Raez, Luis E., Rolfo, Christian* |
| بيانات النشر: | Elsevier Ireland Ltd |
| سنة النشر: | 2016 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | B-Raf, B-Raf inhibitor, Drug, Mutation, NSCLC, Carcinoma, Non-Small-Cell Lung, Drug Resistance, Neoplasm, Human, Lung Neoplasm, Protein Kinase Inhibitor, Proto-Oncogene Proteins B-raf, Hematology, Oncology |
| الوصف: | B-Raf mutations occur in about 1-2% of non-small cell lung cancers (NSCLC). These mutations generate a permanent activation of the mitogen activated protein kinase (MAPK) pathway, which promotes tumor growth and proliferation. In the present review, we discuss B-Raf mutation epidemiology, diagnostic methods to detect B-Raf mutations, the role of B-Raf as a driver mutation and a potential therapeutic target in NSCLC. The results of clinical trials involving B-Raf or MAPK pathway inhibitors for the treatment of NSCLC are also discussed. Clinical trials evaluating B-Raf inhibitors in BRAF mutated NSCLC patients have shown promising results, and larger prospective studies are warranted to validate these findings. Enrollment of these patients in clinical trials is an interesting strategy to offer a potentially more effective and less toxic targeted therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26960735; info:eu-repo/semantics/altIdentifier/wos/WOS:000376218000004; volume:101; firstpage:32; lastpage:39; numberofpages:8; journal:CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY; http://hdl.handle.net/10447/295328Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84959535050; www.elsevier.com/locate/critrevonc |
| DOI: | 10.1016/j.critrevonc.2016.02.012 |
| الإتاحة: | https://doi.org/10.1016/j.critrevonc.2016.02.012Test http://hdl.handle.net/10447/295328Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.95F5AD6B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.critrevonc.2016.02.012 |
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