دورية أكاديمية
Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis
| العنوان: | Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis |
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| المؤلفون: | Ruscitti, Piero, Ursini, Francesco, Cipriani, Paola, Ciccia, Francesco, Liakouli, Vasiliki, Carubbi, Francesco, Guggino, Giuliana, Berardicurti, Onorina, Grembiale, Rosadaniela, Triolo, Giovanni, De Sarro, Giovambattista, Giacomelli, Roberto |
| المساهمون: | Ruscitti, P., Ursini, F., Cipriani, P., Ciccia, F., Liakouli, V., Carubbi, F., Guggino, G., Berardicurti, O., Grembiale, R., Triolo, G., De Sarro, G., Giacomelli, R. |
| بيانات النشر: | Lippincott Williams and Wilkins |
| سنة النشر: | 2017 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | cardiovascular risk, impaired fasting glucose, inflammation, rheumatoid arthriti, type 2 diabete, Adrenal Cortex Hormone, Adult, Aged, Arthritis, Rheumatoid, Blood Glucose, Body Mass Index, C-Reactive Protein, Cardiovascular Disease, Case-Control Studie, Cholesterol, Cross-Sectional Studie, Diabetes Mellitus, Type 2, Female, Glucose Intolerance, Human, Hypertension, Male, Middle Aged, Prevalence, Risk Factor, Time Factor, Medicine (all), Settore MED/16 - Reumatologia |
| الوصف: | Although the better management of rheumatoid arthritis (RA) has significantly improved the long-term outcome of affected patients, a significant proportion of these may develop associated comorbidities including cardiometabolic complications. However, it must be pointed out that a comprehensive cardiometabolic evaluation is still poorly integrated into the management of RA patients, due to a limited awareness of the problem, a lack of appropriate clinical studies, and optimal strategies for cardiovascular (CV) risk reduction in RA. In addition, although several studies investigated the possible association between traditional CV risk factors and RA, conflicting results are still available. On this basis, we planned this cross-sectional study, aimed at investigating the prevalence of type 2 diabetes (T2D) and impaired fasting glucose (IFG) in RA patients compared with age- and gender- matched control individuals. Furthermore, we analyzed the role of both traditional and RA-related CV risk factors in predicting T2D and IFG. We observed an increased prevalence of T2D in RA patients when compared with age- and gender-matched controls. Regression analyses demonstrated that the presence of high blood pressure (HBP), a longer disease duration, and exposure to corticosteroids (CCS) were significantly associated with an increased likelihood of being classified as T2D. In addition, we observed an increased prevalence of IFG in RA patients when compared with age- and gender-matched controls. Regression analyses demonstrated that a higher body mass index (BMI), the presence of metabolic syndrome (MetS), higher levels of total cholesterol, the presence of radiographic damage, and higher serum levels of C-reactive protein (CRP) were significantly associated with an increased likelihood of presenting IFG. In this cross-sectional study, we observed an increased prevalence of T2D and IFG in an Italian cohort of RA patients when compared with age- and gender-matched control individuals. Interestingly, both RA-specific features, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/28834907; info:eu-repo/semantics/altIdentifier/wos/WOS:000408504800044; volume:96; issue:34; firstpage:e7896; numberofpages:8; journal:MEDICINE; http://hdl.handle.net/10447/245711Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85028694901; http://journals.lww.com/md-journalTest |
| DOI: | 10.1097/MD.0000000000007896 |
| الإتاحة: | https://doi.org/10.1097/MD.0000000000007896Test http://hdl.handle.net/10447/245711Test http://journals.lww.com/md-journalTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.389D2A61 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/MD.0000000000007896 |
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