دورية أكاديمية
Semaglutide reduces fat accumulation in the tongue: A randomized single-blind, pilot study
| العنوان: | Semaglutide reduces fat accumulation in the tongue: A randomized single-blind, pilot study |
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| المؤلفون: | Jensterle M., Ferjan S., Vovk A., Battelino T., Rizzo M., Janez A. |
| المساهمون: | Jensterle M., Ferjan S., Vovk A., Battelino T., Rizzo M., Janez A. |
| بيانات النشر: | Elsevier Ireland Ltd |
| سنة النشر: | 2021 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | Glucagon like peptide-1 receptor, Obesity, PCOS, Semaglutide, Tongue fat, Adult, Double-Blind Method, Female, Glucagon-Like Peptides, Humans, Pilot Projects, Single-Blind Method, Adiposity, Tongue |
| الوصف: | Aim: We evaluated the effect of the latest GLP-1 RA semaglutide on tongue fat storage in obese women. Design. We conducted a randomized single-blind, pilot study. Methods: Twenty-five obese women with polycystic ovary syndrome (PCOS) (33.7 ± 5.3 years, body mass index (BMI) 36.1 ± 3.9 kg/m2, mean ± SD) were randomized to semaglutide 1.0 mg or placebo for 16 weeks. We quantified tongue volume and its fat tissue and fat proportion by magnetic resonance imaging. Results: Tongue fat tissue and fat proportion significantly reduced after semaglutide vs placebo (-1.94 ± 5.51 vs. + 3.12 ± 4.87 cm3, p = 0.022, and −0.02 ± 0.07 vs. 0.04 ± 0.06, p = 0.010, respectively). Correlation analysis revealed that these reductions were associated with those in body weight, BMI and waist circumference (p = 0.010 for all). Conclusions: This is the first study confirming the beneficial effect of semaglutide on tongue structure in obese women with PCOS. Further studies are needed to assess the clinical importance of such findings. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34217774; info:eu-repo/semantics/altIdentifier/wos/WOS:000693246300026; volume:178; numberofpages:6; journal:DIABETES RESEARCH AND CLINICAL PRACTICE; http://hdl.handle.net/10447/549465Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85110244495 |
| DOI: | 10.1016/j.diabres.2021.108935 |
| الإتاحة: | https://doi.org/10.1016/j.diabres.2021.108935Test http://hdl.handle.net/10447/549465Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.252449E6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.diabres.2021.108935 |
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