دورية أكاديمية
Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study
| العنوان: | Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study |
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| المؤلفون: | Vasto S., Di Gaudio F., Raso M., Sabatino L., Caldarella R., De Pasquale C., Di Rosa L., Baldassano S. |
| المساهمون: | Vasto S., Di Gaudio F., Raso M., Sabatino L., Caldarella R., De Pasquale C., Di Rosa L., Baldassano S. |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | Biofortification, GIP, Gut peptides, Human health, Lettuce, Minerals, PYY, Blood Glucose, Gastric Inhibitory Polypeptide, Glucagon-Like Peptide 1, Glucagon-Like Peptide 2, Glucose, Homeostasis, Humans, Insulin, Peptide YY, Diabetes Mellitus, Type 2, Food, Fortified, Insulin Resistance, Molybdenum |
| الوصف: | Diabetes is expected to increase up to 700 million people worldwide with type 2 diabetes being the most frequent. The use of nutritional interventions is one of the most natural approaches for managing the disease. Minerals are of paramount importance in order to preserve and obtain good health and among them molybdenum is an essential component. There are no studies about the consumption of biofortified food with molybdenum on glucose homeostasis but recent studies in humans suggest that molybdenum could exert hypoglycemic effects. The present study aims to assess if consumption of lettuce biofortified with molybdenum influences glucose homeostasis and whether the effects would be due to changes in gastrointestinal hormone levels and specifically Peptide YY (PYY), Glucagon-Like Peptide 1 (GLP-1), Glucagon-Like Peptide 2 (GLP-2), and Gastric Inhibitory Polypeptide (GIP). A cohort of 24 people was supplemented with biofortified lettuce for 12 days. Blood and urine samples were obtained at baseline (T0) and after 12 days (T2) of supplementation. Blood was analyzed for glucose, insulin, insulin resistance, β-cell function, and insulin sensitivity, PYY, GLP-1, GLP-2 and GIP. Urine samples were tested for molybdenum concentration. The results showed that consumption of lettuce biofortified with molybdenum for 12 days did not affect beta cell function but significantly reduced fasting glucose, insulin, insulin resistance and increased insulin sensitivity in healthy people. Consumption of biofortified lettuce did not show any modification in urine concentration of molybdenum among the groups. These data suggest that consumption of lettuce biofortified with molybdenum improves glucose homeostasis and PYY and GIP are involved in the action mechanism. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35405964; info:eu-repo/semantics/altIdentifier/wos/WOS:000780620900001; volume:14; issue:7; numberofpages:11; journal:NUTRIENTS; http://hdl.handle.net/10447/552078Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85126958049 |
| DOI: | 10.3390/nu14071351 |
| الإتاحة: | https://doi.org/10.3390/nu14071351Test http://hdl.handle.net/10447/552078Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.AFE60277 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu14071351 |
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