دورية أكاديمية
Drug-utilisation profiles and COVID-19
| العنوان: | Drug-utilisation profiles and COVID-19 |
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| المؤلفون: | Orlando V., Coscioni E., Guarino I., Mucherino S., Perrella A., Trama U., Limongelli G., Menditto E. |
| المساهمون: | Orlando, V., Coscioni, E., Guarino, I., Mucherino, S., Perrella, A., Trama, U., Limongelli, G., Menditto, E. |
| سنة النشر: | 2021 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Adolescent, Adult, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitor, COVID-19, Child, Preschool, Female, Human, Infant, Newborn, Italy, Male, Middle Aged, Renin-Angiotensin System, SARS-CoV-2, Young Adult, Drug Utilization Review |
| الوصف: | Coronavirus disease 2019 (COVID-19) has substantially challenged healthcare systems worldwide. By investigating population characteristics and prescribing profiles, it is possible to generate hypotheses about the associations between specific drug-utilisation profiles and susceptibility to COVID-19 infection. A retrospective drug-utilisation study was carried out using routinely collected information from a healthcare database in Campania (Southern Italy). We aimed to discover the prevalence of drug utilisation (monotherapy and polytherapy) in COVID-19 versus non-COVID-19 patients in Campania (~ 6 million inhabitants). The study cohort comprised 1532 individuals who tested positive for COVID-19. Drugs were grouped according to the Anatomical Therapeutic Chemical (ATC) classification system. We noted higher prevalence rates of the use of drugs in the ATC categories C01, B01 and M04, which was probably linked to related comorbidities (i.e., cardiovascular and metabolic). Nevertheless, the prevalence of the use of drugs acting on the renin-angiotensin system, such as antihypertensive drugs, was not higher in COVID-19 patients than in non-COVID-19 patients after adjustments for age and sex. These results highlight the need for further case-control studies to define the effects of medications and comorbidities on susceptibility to and associated mortality from COVID-19. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000647144000007; volume:11; issue:1; firstpage:8913; journal:SCIENTIFIC REPORTS; http://hdl.handle.net/11588/878723Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85105718631 |
| DOI: | 10.1038/s41598-021-88398-y |
| الإتاحة: | https://doi.org/10.1038/s41598-021-88398-yTest http://hdl.handle.net/11588/878723Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3D3F3DBF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-021-88398-y |
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