المؤلفون: Canonico R., Flammini F., Marrone S., Nardone R., Vittorini V.

المساهمون: Margaria, T., Steffen, B., Canonico, R., Flammini, F., Marrone, S., Nardone, R., Vittorini, V.

مصطلحات موضوعية: Railways, ERTMS/ETCS, FRMCS, NG2R, SDN, Control plane, QoS, Formal methods, MDE, DSTM

الوصف: The emergence of 5G technologies opens up new opportunities for railway communications. One of the foundational aspects of 5G architecture is its control-plane programmability, which can be achieved through Software Defined Networking (SDN). In railway scenarios, this can be used to dynamically reconfigure the network for a more effective and efficient management of communication flows produced by moving trains. The paper presents a framework for integrating modelling and analysis tools into a programmable control plane specifically tailored to railway communications. We introduce the concept of domain-awareness in the network control plane as an SDN-enabled feature that allows achieving application-specific advantages besides those purely expressed in terms of key performance indicators such as the quality of service. We propose a reference architecture in which domain-awareness in the control plane is obtained by considering information gathered by network devices and ad-hoc communication gateways that are able to detect relevant signalling events. In the architecture, the actual behaviour of the SDN controller is governed by applications that are able to react to specific triggers and re-configure network devices accordingly. We also provide a methodological framework based on model-driven engineering and formal methods, including dynamic state machines, for the automatic generation of SDN control plane logic.

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/978-3-031-19761-1; info:eu-repo/semantics/altIdentifier/isbn/978-3-031-19762-8; ispartofbook:Leveraging Applications of Formal Methods, Verification and Validation. Practice. ISoLA 2022.; volume:13704 LNCS; firstpage:308; lastpage:320; numberofpages:13; serie:LECTURE NOTES IN COMPUTER SCIENCE; info:eu-repo/grantAgreement/EC/H2020/101015416; alleditors:Margaria, T., Steffen, B.; https://hdl.handle.net/11588/913478Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85142692213; https://link.springer.com/chapter/10.1007/978-3-031-19762-8_23Test

الإتاحة: https://doi.org/10.1007/978-3-031-19762-8_23Test
https://hdl.handle.net/11588/913478Test

المؤلفون: De Donato, Lorenzo, Flammini, Francesco, Marrone, Stefano, Mazzariello, Claudio, Nardone, Roberto, Sansone, Carlo, Vittorini, Valeria

المساهمون: De Donato, Lorenzo, Flammini, Francesco, Marrone, Stefano, Mazzariello, Claudio, Nardone, Roberto, Sansone, Carlo, Vittorini, Valeria

الوصف: Within Artificial Intelligence, Deep Learning (DL) represents a paradigm that has been showing unprecedented performance in image and audio processing by supporting or even replacing humans in defect and anomaly detection. The Railway sector is expected to benefit from DL applications, especially in predictive maintenance applications, where smart audio and video sensors can be leveraged yet kept distinct from safety-critical functions. Such separation is crucial, as it allows for improving system dependability with no impact on its safety certification. This is further supported by the development of DL in other transportation domains, such as automotive and avionics, opening for knowledge transfer opportunities and highlighting the potential of such a paradigm in railways. In order to summarize the recent state-of-the-art while inquiring about future opportunities, this paper reviews DL approaches for the analysis of data generated by acoustic and visual sensors in railway maintenance applications that have been published until August 31st, 2021. In this paper, the current state of the research is investigated and evaluated using a structured and systematic method, in order to highlight promising approaches and successful applications, as well as to identify available datasets, current limitations, open issues, challenges, and recommendations about future research directions.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000815504500001; volume:10; firstpage:65376; lastpage:65400; numberofpages:25; journal:IEEE ACCESS; info:eu-repo/grantAgreement/EC/H2020/881782; https://hdl.handle.net/11588/888435Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85132784354

الإتاحة: https://doi.org/10.1109/ACCESS.2022.3183102Test
https://hdl.handle.net/11588/888435Test

المؤلفون: Giulio Zuccaro, Daniela De Gregorio, Mattia Federico Leone, Salvatore Sessa, Stefano Nardone, Francesca Linda Perelli

المساهمون: Zuccaro, Giulio, DE GREGORIO, Daniela, Leone, MATTIA FEDERICO, Sessa, Salvatore, Nardone, Stefano, Perelli, FRANCESCA LINDA

مصطلحات موضوعية: seismic risk, emergency planning, energy retrofit

الوصف: Italy is a country with high seismic hazard, however since the delay in the seismic classification of the national territory, most of the existing building heritage does not comply with the current technical standards for buildings. The seismic events that have hit different Italian regions in recent years have highlighted the complexity of the challenge for the public bodies both in the emergency management and post‐event reconstruction and in the planning of effective risk prevention and mitigation measures to be implemented in ‘peacetime’. These difficulties concern, in particular, the capacity to properly manage the financial and technical resources available and to identify the intervention priorities throughout the entire emergency cycle. For correct management, the priority is to quantify and localize, through simulations, the quantification of probable damages and to evaluate in terms of cost‐benefits the possible alternative strategies for mitigation, also taking into account the potential, in terms of cost‐effectiveness, of integrated measures for seismic and energy retrofitting. In this framework, the project CAESAR II (Complementary Analyses for Emergency planning based on Seismic Risks impact evaluations) has been developed as a Decision Support System for Public Authorities in charge of developing Disaster Risk Reduction plans, with the possibility of programming mid to long‐term investments for public and private properties, as well as defining custom financial support mechanisms and tax incentives.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000694491400001; volume:13; firstpage:9838; lastpage:9859; numberofpages:22; journal:SUSTAINABILITY; http://hdl.handle.net/11588/856543Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85114238910; https://www.mdpi.com/2071-1050/13/17/9838Test

الإتاحة: https://doi.org/10.3390/su13179838Test
http://hdl.handle.net/11588/856543Test
https://www.mdpi.com/2071-1050/13/17/9838Test

المؤلفون: Montuori P., De Rosa E., Di Duca F., Provvisiero D. P., Sarnacchiaro P., Nardone A., Triassi M.

المساهمون: Montuori, P., De Rosa, E., Di Duca, F., Provvisiero, D. P., Sarnacchiaro, P., Nardone, A., Triassi, M.

مصطلحات موضوعية: Composite indicator, Contaminant load, Polycyclic aromatic hydrocarbon, Risk assessment, Volturno River, China, Environmental Monitoring, Geologic Sediment, Italy, Mediterranean Sea, River, Water Pollutants, Chemical

الوصف: This study reports the data on the contamination caused by polycyclic aromatic hydrocarbons (PAHs) drained from the Volturno River. The seasonal and spatial distribution of PAHs in water and sediment samples was assessed. The 16 PAHs were determined in the water dissolved phase (DP), suspended particulate matter (SPM), and sediments. A multidimensional statistical approach was used to identify three pollution composite indicators. Contaminant discharges of PAHs into the sea were calculated in about 3158.2 kg/year. Total concentrations of PAHs varied in ranges 434.8 to 872.1 ng g−1 and 256.7 to 1686.3 ng L−1 in sediment samples and in water (DP + SPM), respectively. The statistical results indicated that the PAHs mainly had a pyrolytic source. Considering the sediment quality guidelines (SQGs), the water environmental quality standards (USEPA EQS), and risk quotient (RQ), the Volturno River would be considered as an area in which the environmental integrity is possibly at risk.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000623579300001; volume:18; issue:4; firstpage:1; lastpage:19; numberofpages:19; journal:INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH; http://hdl.handle.net/11588/868632Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100275444; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913333/pdf/ijerph-18-01383.pdfTest

الإتاحة: https://doi.org/10.3390/ijerph18041383Test
http://hdl.handle.net/11588/868632Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913333/pdf/ijerph-18-01383.pdfTest

المؤلفون: Nardelli C, Granata I, D'Argenio V, Tramontano S, Compare D, Guarracino M R, Nardone G, Pilone V, Sacchetti L

المساهمون: Nardelli, C, Granata, I, D'Argenio, V, Tramontano, S, Compare, D, Guarracino, M R, Nardone, G, Pilone, V, Sacchetti, L

مصطلحات موضوعية: duodenum, microbiome, obesity

الوصف: The gut microbiota may have an impact on obesity. To date, the majority of studies in obese patients reported microbiota composition in stool samples. The aim of this study was to investigate the duodenal mucosa dysbiosis in adult obese individuals from Campania, a region in Italy with a very high percentage of obese people, to highlight microbial taxa likely associated with obesity. Duodenum biopsies were taken during upper gastrointestinal endoscopy in 19 obese (OB) and 16 lean control subjects (CO) and microbiome studied by 16S rRNA gene sequencing. Duodenal microbiome in our groups consisted of six phyla: Proteobacteria, Firmicutes, Actinobacteria, Fusobacteria, Bacteroidetes and Acidobacteria. Proteobacteria (51.1% vs. 40.1%) and Firmicutes (33.6% vs. 44.9%) were significantly (p < 0.05) more and less abundant in OB compared with CO, respectively. Oribacterium asaccharolyticum, Atopobium parvulum and Fusobacterium nucleatum were reduced (p < 0.01) and Pseudomonadales were increased (p < 0.05) in OB compared with CO. Receiver operating characteristic curve analysis showed Atopobium and Oribacterium genera able to discriminate with accuracy (power = 75% and 78%, respectively) OB from CO. In conclusion, increased Proteobacteria and decreased Firmicutes (Lachnospiraceae) characterized the duodenal microbiome of obese subjects. These data direct to further studies to evaluate the functional role of the dysbiotic-obese-associated signature.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000533510400084; volume:8; issue:4; firstpage:485; journal:MICROORGANISMS; http://hdl.handle.net/11588/801721Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85083251362

الإتاحة: https://doi.org/10.3390/microorganisms8040485Test
http://hdl.handle.net/11588/801721Test

المؤلفون: Maria Pia Sormani, Irene Schiavetti, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Vincenzo Brescia Morra, Maria Trojano, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Yara Dadalti Fragoso, Sedat Sen, Aksel Siva, Roberto Furlan, Marco Salvetti, MuSC-19 Study Group Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, Rossi Beatrice Maria Allegri, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, Mario A Battaglia, Alessandra Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Morra Vincenzo Brescia, Giampaolo Brichetto, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Maria Caniatti, Roberto Cantello, Ruggero Capra, Rocco Capuano, Patrizia Carta, Paola Cavalla, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Chisari, Raffaella Clerici, Marinella Clerico, Eleonora Cocco, Gaia Cola, Paolo Confalonieri, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d'Ambrosio, Emanuele D'Amico, Maura Chiara Danni, Alessia d'Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Stefano, Marco Della Cava, Mario di Napoli, Alessia Di Sapio, Renato Docimo, Anna Dutto, Luana Evangelista, Salvatore Fanara, Diana Ferraro, Maria Teresa Ferrò, Massimo Filippi, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Daniele Imperiale, Maria Teresa Infante, Matilde Inglese, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, Rita L'Episcopo Maria, Serena Leva, Giuseppe Liberatore, Marianna Lo Re, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Rosa Mancinelli, Luca Mancinelli, Paolo Manganotti, Teresa Giorgia Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, Alessandra Girolama Marfia, Fabiana Marinelli, Alessandro Marti, Filippo Martinelli Boneschi, Federco Masserano Zoli, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Sara Montepietra, Margherita Monti Bragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile-Orazio, Agostino Nozzolillo, Marco Onofrj, Riccardo Orlandi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Elisabetta Pedrazzoli, Paola Perini, Ilaria Pesci, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Calogero Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Cinzia Scandellari, Ilaria Scarano Giuditta, Valentina Scarano, Valentina Schillaci, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Laura Emanuela Susani, Giulietta Tabiadon, Francesco Teatini, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Trotta, Gabriella Turano, Monica Ulivelli, Manzo Valentino, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Antonio Zito, Luigi Zuliani

المساهمون: Pia Sormani, Maria, Schiavetti, Irene, Landi, Doriana, Carmisciano, Luca, De Rossi, Nicola, Cordioli, Cinzia, Moiola, Lucia, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, Brescia Morra, Vincenzo, Trojano, Maria, Tedeschi, Gioacchino, Comi, Giancarlo, Alberto Battaglia, Mario, Patti, Francesco, Dadalti Fragoso, Yara, Sen, Sedat, Siva, Aksel, Furlan, Roberto, Salvetti, Marco, Study Group Gianmarco Abbadessa, MuSC-19, Aguglia, Umberto, Allegorico, Lia, Beatrice Maria Allegri, Rossi, Pia Amato, Maria, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, A Battaglia, Mario, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Vincenzo Brescia, Morra, Brichetto, Giampaolo, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Chiara Buscarinu, Maria, Paola Cabboi, Maria, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Maria Caniatti, Luisa, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Cavalla, Paola, Grazia Celani, Maria, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cocco, Eleonora, Cola, Gaia, Confalonieri, Paolo, Conte, Antonella, Zaffira Conti, Marta, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, D'Ambrosio, Alessandro, D'Amico, Emanuele, Chiara Danni, Maura, D'Arma, Alessia, Dattola, Vincenzo, de Biase, Stefano, De Luca, Giovanna, Federica De Mercanti, Stefania, De Mitri, Paolo, De Stefano, Nicola

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000679697800001; journal:MULTIPLE SCLEROSIS; http://hdl.handle.net/11588/863766Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85111703879

الإتاحة: http://hdl.handle.net/11588/863766Test

المؤلفون: Sormani MP, De Rossi N, Schiavetti I, Carmisciano L, Cordioli C, Moiola L, Radaelli M, Immovilli P, Capobianco M, Trojano M, Zaratin P, Tedeschi G, Comi G, Battaglia MA, Patti F, Salvetti M, Musc-19 Study Group Agostino Nozzolillo, Alessandra Bellacosa, Alessandra Protti, Alessia Di Sapio, Alessio Signori, Alfredo Petrone, Alvino Bisecco, Aniello Iovino, Anna Dutto, Anna Maria Repice, Antonella Conte, Antonio Bertolotto, Antonio Bosco, Antonio Gallo, Antonio Zito, Arianna Sartori, Bruno Giometto, Carla Tortorella, Carlo Antozzi, Carlo Pozzilli, Chiara Rosa Mancinelli, Chiara Zanetta, Christian Cordano, Cinzia Cordioli, Cinzia Scandellari, Clara Guaschino, Claudio Gasperini, Claudio Solaro, Cristina Fioretti, Daiana Bezzini, Damiano Marastoni, Damiano Paolicelli, Domizia Vecchio, Doriana Landi, Elisabetta Bucciantini, Elisabetta Pedrazzoli, Elisabetta Signoriello, Elvira Sbragia, Emanuela Laura Susani, Erica Curti, Eva Milano, Fabiana Marinelli, Federico Camilli, Filippo Martinelli Boneschi, Flora Govone, Francesca Bovis, Francesca Calabria, Francesca Caleri, Francesca Rinaldi, Francesca Vitetta, Francesco Corea, Francesco Crescenzo, Francesco Patti, Francesco Teatini, Giulietta Tabiadon, Franco Granella, Giacomo Boffa, Giacomo Lus, Giampaolo Brichetto, Giancarlo Comi, Gioacchino Tedeschi, Giorgia Teresa Maniscalco, Giovanna Borriello, Giovanna De Luca, Giovanna Konrad, Giovanna Vaula, Girolama Alessandra Marfia, Giulia Mallucci, Giuseppe Liberatore, Giuseppe Salemi, Giuseppina Miele, Grazia Sibilia, Ilaria Pesci, Irene Schiavetti, Laura Brambilla, Leonardo Lopiano, Leonardo Sinisi, Livia Pasquali, Lorenzo Saraceno, Luca Carmisciano, Luca Chiveri, Luca Mancinelli, Lucia Moiola, Luigi M. E. Grimaldi, Luisa Maria Caniatti, Marco Capobianco, Marco Della Cava, Marco Onofrj, Marco Rovaris, Marco Salvetti, Marco Vercellino, Margherita Monti Bragadin, Maria Buccafusca, Maria Chiara Buscarinu, Maria Grazia Celani, Maria Grazia Grasso, Maria Laura Stromillo, Maria Petracca, Maria Pia Amato, Maria Pia Sormani, Maria Rita L'Episcopo, Maria Sessa, Maria Teresa Ferrò, Maria Trojano, Maria Vittoria Ercolani, Mariangela Bianco, Marianna Lo Re, Marika Vianello, Marinella Clerico, Mario Alberto Battaglia, Mario di Napoli, Marta Ponzano, Marta Radaelli, Marta Zaffira Conti, Massimiliano Calabrese, Massimiliano Mirabella, Massimo Filippi, Matilde Inglese, Matteo Lucchini, Matteo Pozzato, Maura Chiara Danni, Mauro Zaffaroni, Mauro Zampolini, Michela Ponzio, Milena De Riz, Nicola De Rossi, Nicola De Stefano, Paola Cavalla, Paola De Mitri, Paola Grossi, Paola Zaratin, Paolo Confalonieri, Paolo Gallo, Paolo Immovilli, Paolo Ragonese, Patrizia Sola, Pietro Annovazzi, Pietro Iaffaldano, Raffaele Nardone, Raffaella Cerqua, Raffaella Clerici, Roberta Lanzillo, Roberta Motta, Roberto Balgera, Roberto Bergamaschi, Rocco Totaro, Rosa Iodice, Ruggero Capra, Sabrina Marangoni, Sabrina Realmuto, Salvatore Cottone, Sara Montepietra, Sarah Rasia, Sebastiano Arena, Sebastiano Bucello, Silvia Banfi, Simona Bonavita, Simona Malucchi, Simone Tonietti, Stefano Vollaro, Susanna Cordera, Umberto Aguglia, Valentina Torri Clerici, Valeria Barcella, Valeria Bergamaschi, Vincenzo Brescia Morra, Vincenzo Dattola, and Vittorio Mantero

المساهمون: Mp, Sormani, N, De Rossi, I, Schiavetti, L, Carmisciano, C, Cordioli, L, Moiola, M, Radaelli, P, Immovilli, M, Capobianco, M, Trojano, P, Zaratin, G, Tedeschi, G, Comi, Ma, Battaglia, F, Patti, M, Salvetti, Study Group Agostino Nozzolillo, Musc-19, Bellacosa, Alessandra, Protti, Alessandra, Di Sapio, Alessia, Signori, Alessio, Petrone, Alfredo, Bisecco, Alvino, Iovino, Aniello, Dutto, Anna, Maria Repice, Anna, Conte, Antonella, Bertolotto, Antonio, Bosco, Antonio, Gallo, Antonio, Zito, Antonio, Sartori, Arianna, Giometto, Bruno, Tortorella, Carla, Antozzi, Carlo, Pozzilli, Carlo, Rosa Mancinelli, Chiara, Zanetta, Chiara, Cordano, Christian, Cordioli, Cinzia, Scandellari, Cinzia, Guaschino, Clara, Gasperini, Claudio, Solaro, Claudio, Fioretti, Cristina, Bezzini, Daiana, Marastoni, Damiano, Paolicelli, Damiano, Vecchio, Domizia, Landi, Doriana, Bucciantini, Elisabetta, Pedrazzoli, Elisabetta, Signoriello, Elisabetta, Sbragia, Elvira, Laura Susani, Emanuela, Curti, Erica, Milano, Eva, Marinelli, Fabiana, Camilli, Federico, Martinelli Boneschi, Filippo, Govone, Flora, Bovis, Francesca, Calabria, Francesca, Caleri, Francesca, Rinaldi, Francesca, Vitetta, Francesca, Corea, Francesco, Crescenzo, Francesco, Patti, Francesco, Teatini, Francesco, Tabiadon, Giulietta, Granella, Franco, Boffa, Giacomo, Lus, Giacomo, Brichetto, Giampaolo, Comi, Giancarlo, Tedeschi, Gioacchino, Teresa Maniscalco, Giorgia, Borriello, Giovanna, De Luca, Giovanna, Konrad, Giovanna, Vaula, Giovanna, Alessandra Marfia, Girolama, Mallucci, Giulia, Liberatore, Giuseppe, Salemi, Giuseppe, Miele, Giuseppina, Sibilia, Grazia, Pesci, Ilaria, Schiavetti, Irene, Brambilla, Laura, Lopiano, Leonardo, Sinisi, Leonardo, Pasquali, Livia, Saraceno, Lorenzo, Carmisciano, Luca, Chiveri, Luca, Mancinelli, Luca, Moiola, Lucia, Grimaldi, Luigi M. E.

الوصف: Objective: This study was undertaken to assess the impact of immunosuppressive and immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID-19) in people with multiple sclerosis (PwMS). Methods: We retrospectively collected data of PwMS with suspected or confirmed COVID-19. All the patients had complete follow-up to death or recovery. Severe COVID-19 was defined by a 3-level variable: mild disease not requiring hospitalization versus pneumonia or hospitalization versus intensive care unit (ICU) admission or death. We evaluated baseline characteristics and MS therapies associated with severe COVID-19 by multivariate and propensity score (PS)-weighted ordinal logistic models. Sensitivity analyses were run to confirm the results. Results: Of 844 PwMS with suspected (n = 565) or confirmed (n = 279) COVID-19, 13 (1.54%) died; 11 of them were in a progressive MS phase, and 8 were without any therapy. Thirty-eight (4.5%) were admitted to an ICU; 99 (11.7%) had radiologically documented pneumonia; 96 (11.4%) were hospitalized. After adjusting for region, age, sex, progressive MS course, Expanded Disability Status Scale, disease duration, body mass index, comorbidities, and recent methylprednisolone use, therapy with an anti-CD20 agent (ocrelizumab or rituximab) was significantly associated (odds ratio [OR] = 2.37, 95% confidence interval [CI] = 1.18-4.74, p = 0.015) with increased risk of severe COVID-19. Recent use (<1 month) of methylprednisolone was also associated with a worse outcome (OR = 5.24, 95% CI = 2.20-12.53, p = 0.001). Results were confirmed by the PS-weighted analysis and by all the sensitivity analyses. Interpretation: This study showed an acceptable level of safety of therapies with a broad array of mechanisms of action. However, some specific elements of risk emerged. These will need to be considered while the COVID-19 pandemic persists.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000616353600001; volume:4; firstpage:780; lastpage:789; numberofpages:10; journal:ANNALS OF NEUROLOGY; http://hdl.handle.net/11588/863762Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100758179

الإتاحة: https://doi.org/10.1002/ana.26028Test
http://hdl.handle.net/11588/863762Test

المؤلفون: Nardone, Olga Maria, Iacucci, Marietta, Villanacci, Vincenzo, Peyrin-Biroulet, Laurent, Ghosh, Subrata, Danese, Silvio, Parigi, Tommaso Lorenzo

المساهمون: Nardone, Olga Maria, Iacucci, Marietta, Villanacci, Vincenzo, Peyrin-Biroulet, Laurent, Ghosh, Subrata, Danese, Silvio, Parigi, Tommaso Lorenzo

مصطلحات موضوعية: UC, artificial intelligence, deep remission, endoscopy, histological healing, histological index, histology, mucosal healing, reporting, ulcerative colitis

الوصف: Background: Treatment targets of ulcerative colitis (UC) have evolved to include not only endoscopic but also histologic remission. However, the concept of histological activity is still in its early days. We aimed to capture the attitudes toward UC histology and the uptake of standardized reporting of endoscopy and histology of UC in daily practice. Methods: We conducted a cross-sectional survey of physicians involved in the care of inflammatory bowel disease worldwide. The survey included 21 questions divided into three sections. The first recorded demographics, specialty, and level of experience of participants; the second covered clinical practices and attitudes toward the use and reporting of endoscopy; and the third covered histology. Results: In total, 359 participants from 60 countries and all levels of experience completed the survey. UC histology was used by nearly all respondents (90.5%) for initial diagnosis, by 72% to monitor disease course, by 62.4% to determine the microscopic extension, by 59.9% to confirm deep remission when considering to stop treatment, and 42.3% to increase/optimize treatment. Nevertheless 77.2% of participants reported that no standard histological index was available in their daily practice. Instead, endoscopy reports included the Mayo Endoscopic score in 90% of cases. The majority of respondents welcomed as useful or very useful an artificial intelligence system to automate scoring of endoscopy (69%) or histology (73%). Conclusion: UC histology reports are less standard than endoscopy reports, although most physicians consider histological activity useful when managing UC and would welcome artificial intelligence systems to automate endoscopic and histological scoring.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:001006405700001; volume:11; issue:6; firstpage:514; lastpage:519; numberofpages:6; journal:UNITED EUROPEAN GASTROENTEROLOGY JOURNAL; https://hdl.handle.net/11588/949390Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85162002352

الإتاحة: https://doi.org/10.1002/ueg2.12423Test
https://hdl.handle.net/11588/949390Test

المؤلفون: Nardone, Olga Maria, Armuzzi, Alessandro

المساهمون: Nardone, Olga Maria, Armuzzi, Alessandro

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:001038641900001; volume:55; issue:7; firstpage:829; lastpage:830; numberofpages:2; journal:DIGESTIVE AND LIVER DISEASE; https://hdl.handle.net/11588/949393Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85153333800

الإتاحة: https://doi.org/10.1016/j.dld.2023.04.014Test
https://hdl.handle.net/11588/949393Test

المؤلفون: Parigi, Tommaso Lorenzo, Cannatelli, Rosanna, Nardone, Olga Maria, Zammarchi, Irene, Shivaji, Uday, Furfaro, Federica, Zardo, Davide, Spaggiari, Paola, Del Sordo, Rachele, Setti, Orsola, Majumder, Snehali, Smith, Samuel Charles Lloyd, Danese, Silvio, Armuzzi, Alessandro, Villanacci, Vincenzo, Ghosh, Subrata, Iacucci, Marietta

المساهمون: Parigi, Tommaso Lorenzo, Cannatelli, Rosanna, Nardone, Olga Maria, Zammarchi, Irene, Shivaji, Uday, Furfaro, Federica, Zardo, Davide, Spaggiari, Paola, Del Sordo, Rachele, Setti, Orsola, Majumder, Snehali, Smith, Samuel Charles Lloyd, Danese, Silvio, Armuzzi, Alessandro, Villanacci, Vincenzo, Ghosh, Subrata, Iacucci, Marietta

مصطلحات موضوعية: PHRI, PICaSSO, endoscopic remission, histological remission, inflammatory bowel disease, neutrophils

الوصف: Backgrounds and aims: Absence of neutrophils is the minimum standard to consider histological remission of ulcerative colitis (UC). The PICaSSO Histological remission Index (PHRI) is a new simple index for UC based only on the detection of neutrophils. We evaluate PHRI's correlation with endoscopy and its prognostic value compared to other established indices. Methods: Consecutive patients with UC underwent colonoscopy at 2 referral centres (Birmingham, UK and Milan, Italy) and were followed up for 2 years. Correlation between histology (PHRI, Nancy [NHI] and Robarts [RHI]) and endoscopy (Mayo Endoscopic Score [MES]; Ulcerative Colitis Severity Endoscopic Index of Severity [UCEIS], and PICaSSO score) was calculated as Spearman coefficients. Diagnostic performance of endoscopy was assessed with ROC curves and outcome stratification with Kaplan-meier curves. Results: 192 patients with UC were enrolled, representing all grades of endoscopic severity. Correlation between histology and endoscopy did not differ significantly when using PHRI instead of NHI or RHI. In particular, PHRI's correlation with MES, UCEIS and PICaSSO was 0.745, 0.718, and 0.694, respectively. Endoscopically-assessed remission reflected the absence of neutrophils (PHRI = 0) with areas under the ROC curve of 0.905, 0.906, and 0.877 for MES, UCEIS, and PICaSSO, respectively. The hazard ratio for disease flare between patients in histological activity/remission was statistically similar (p>0.05) across indexes (2.752, 2.706, and 2.871 for RHI, NHI, and PHRI, respectively). Conclusion: PHRI correlates with endoscopy and stratifies risk of relapse similarly to RHI and NHI. Neutrophil-only assessment of UC is a simple yet viable alternative to established histological scores.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:001027546500001; journal:JOURNAL OF CROHN'S AND COLITIS; https://hdl.handle.net/11588/949389Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85179178411

الإتاحة: https://doi.org/10.1093/ecco-jcc/jjad110Test
https://hdl.handle.net/11588/949389Test