دورية أكاديمية
Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models
| العنوان: | Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models |
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| المؤلفون: | Zaghini A., Sarli G., Barboni C., Sanapo M., Pellegrino V., Diana A., Linta N., Rambaldi J., D'Apice M. R., Murdocca M., Baleani M., Baruffaldi F., Fognani R., Mecca R., Festa A., Papparella S., Paciello O., Prisco F., Capanni C., Loi M., Schena E., Lattanzi G., Squarzoni S. |
| المساهمون: | Zaghini, A., Sarli, G., Barboni, C., Sanapo, M., Pellegrino, V., Diana, A., Linta, N., Rambaldi, J., D'Apice, M. R., Murdocca, M., Baleani, M., Baruffaldi, F., Fognani, R., Mecca, R., Festa, A., Papparella, S., Paciello, O., Prisco, F., Capanni, C., Loi, M., Schena, E., Lattanzi, G., Squarzoni, S. |
| سنة النشر: | 2020 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Aging, Animal model breeding, Bone strength, Hutchinson-Gilford Progeria Syndrome (HGPS), Kyphosi, Quality of life |
| الوصف: | The transgenic LmnaG609G progeric mouse represents an outstanding animal model for studying the human Hutchinson-Gilford Progeria Syndrome (HGPS) caused by a mutation in the LMNA gene, coding for the nuclear envelope protein Lamin A/C, and, as an important, more general scope, for studying the complex process governing physiological aging in humans. Here we give a comprehensive description of the peculiarities related to the breeding of LmnaG609G mice over a prolonged period of time, and of many features observed in a large colony for a 2-years period. We describe the breeding and housing conditions underlining the possible interference of the genetic background on the phenotype expression. This information represents a useful tool when planning and interpreting studies on the LmnaG609G mouse model, complementing any specific data already reported in the literature about this model since its production. It is also particularly relevant for the heterozygous mouse, which mirrors the genotype of the human pathology however requires an extended time to manifest symptoms and to be carefully studied. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000505771100014; volume:130; firstpage:110784; journal:EXPERIMENTAL GERONTOLOGY; http://hdl.handle.net/11588/817446Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85076030218 |
| DOI: | 10.1016/j.exger.2019.110784 |
| الإتاحة: | https://doi.org/10.1016/j.exger.2019.110784Test http://hdl.handle.net/11588/817446Test |
| رقم الانضمام: | edsbas.CE6A3519 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.exger.2019.110784 |
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