دورية أكاديمية
Sex Differences in Cardiovascular Diseases: A Matter of Estrogens, Ceramides, and Sphingosine 1-Phosphate
| العنوان: | Sex Differences in Cardiovascular Diseases: A Matter of Estrogens, Ceramides, and Sphingosine 1-Phosphate |
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| المؤلفون: | Beatrice Arosio, Graziamaria Corbi, Sergio Davinelli, Vienna Giordano, Daniela Liccardo, Antonio Rapacciuolo, Alessandro Cannavo |
| المساهمون: | Arosio, Beatrice, Corbi, Graziamaria, Davinelli, Sergio, Giordano, Vienna, Liccardo, Daniela, Rapacciuolo, Antonio, Cannavo, Alessandro |
| سنة النشر: | 2022 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | cardiovascular, estrogen, sex difference, sphingolipids |
| الوصف: | The medical community recognizes sex-related differences in pathophysiology and cardiovascular disease outcomes (CVD), culminating with heart failure. In general, pre-menopausal women tend to have a better prognosis than men. Explaining why this occurs is not a simple matter. For decades, sex hormones like estrogens (Es) have been identified as one of the leading factors driving these sex differences. Indeed, Es seem protective in women as their decline, during and after menopause, coincides with an increased CV risk and HF development. However, clinical trials demonstrated that E replacement in post-menopause women results in adverse cardiac events and increased risk of breast cancer. Thus, a deeper understanding of E-related mechanisms is needed to provide a vital gateway toward better CVD prevention and treatment in women. Of note, sphingolipids (SLs) and their metabolism are strictly related to E activities. Among the SLs, ceramide and sphingosine 1-phosphate play essential roles in mammalian physiology, particularly in the CV system, and appear differently modulated in males and females. In keeping with this view, here we explore the most recent experimental and clinical observations about the role of E and SL metabolism, emphasizing how these factors impact the CV system. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000781023900001; volume:23; issue:7; firstpage:4009; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11588/881767Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85127583183 |
| DOI: | 10.3390/ijms23074009 |
| الإتاحة: | https://doi.org/10.3390/ijms23074009Test http://hdl.handle.net/11588/881767Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.A166E4F9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms23074009 |
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