دورية أكاديمية
Silent coronary heart disease in patients with type 2 diabetes: application of a screening approach in a follow-up study
| العنوان: | Silent coronary heart disease in patients with type 2 diabetes: application of a screening approach in a follow-up study |
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| المؤلفون: | Vigili de Kreutzenberg S, Solini A, Vitolo E, Boi A, Bacci S, Cocozza S, Nappo R, Rivellese A, Avogaro A, Baroni MG |
| المساهمون: | Vigili de Kreutzenberg, S, Solini, A, Vitolo, E, Boi, A, Bacci, S, Cocozza, S, Nappo, R, Rivellese, A, Avogaro, A, Baroni, Mg |
| سنة النشر: | 2017 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Silent coronary heart disease ischemia Type 2 diabetes CHD diagnosis Electrocardiogram Diabetes complications Positive predictive value |
| الوصف: | Aims: The cost-effectiveness of screening for silent coronary heart disease (CHD) in type 2 diabetes (DM2) is still debated. Methods: We applied a diagnostic algorithm for silent CHD detection, in a cohort of 102 asymptomatic DM2 subjects (57 ± 7 years), attending 5 Italian outpatient clinics, to verify its predictive value. The risk of silent CHD was calculated considering classical risk factors, and presence of microangiopathy/macroangiopathy. Patients were divided in 3 groups, i.e. group 1: normal ECG and low silent CHD risk; group 2: abnormal ECG, irrespective of silent CHD risk; group 3: high silent CHD risk, irrespective of ECG. To group 2 and 3, a functional test was recommended and performed in 78% of patients. Results: Silent CHD prevalence was similar in group 2 and 3 (25 vs. 17% respectively; p = 0.495). However, evaluating the entire cohort, a significant higher prevalence of silent CHD was observed in subjects with abnormal vs. normal ECG (23 vs. 4%; P = 0.004), but not in subjects with high vs. low pre-test silent CHD risk (14 vs. 9%; p = 0.472). Conclusions: An abnormal ECG was a strong, independent predictor of silent CHD (OR 8.9; CI 1.27–62.5; p = 0.028) in DM2. Therefore, a functional stress testing should be considered in DM2 patients with ECG abnormalities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000402582900006; volume:31; issue:6; firstpage:952; lastpage:957; numberofpages:6; journal:JOURNAL OF DIABETES AND ITS COMPLICATIONS; http://hdl.handle.net/11588/672387Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85017466879 |
| DOI: | 10.1016/j.jdiacomp.2017.03.014 |
| الإتاحة: | https://doi.org/10.1016/j.jdiacomp.2017.03.014Test http://hdl.handle.net/11588/672387Test |
| رقم الانضمام: | edsbas.920338E4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jdiacomp.2017.03.014 |
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