دورية أكاديمية
Homologous Recombination Deficiency in Ovarian Cancer: from the Biological Rationale to Current Diagnostic Approaches
| العنوان: | Homologous Recombination Deficiency in Ovarian Cancer: from the Biological Rationale to Current Diagnostic Approaches |
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| المؤلفون: | Alessandro Mangogna, Giada Munari, Francesco Pepe, Edoardo Maffii, Pierluigi Giampaolino, Giuseppe Ricci, Matteo Fassan, Umberto Malapelle, Stefania Biffi |
| المساهمون: | Mangogna, Alessandro, Munari, Giada, Pepe, Francesco, Maffii, Edoardo, Giampaolino, Pierluigi, Ricci, Giuseppe, Fassan, Matteo, Malapelle, Umberto, Biffi, Stefania |
| سنة النشر: | 2023 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | assay, homologous recombination deficiency (HRD), homologous recombination repair (HRR), next-generation sequencing (NGS), ovarian cancer, poly (ADP-ribose) polymerase inhibitor (PARPi), test |
| الوصف: | The inability to efficiently repair DNA double-strand breaks using the homologous recombination repair pathway is defined as homologous recombination deficiency (HRD). This molecular phenotype represents a positive predictive biomarker for the clinical use of poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors and platinum-based chemotherapy in ovarian cancers. However, HRD is a complex genomic signature, and different methods of analysis have been developed to introduce HRD testing in the clinical setting. This review describes the technical aspects and challenges related to HRD testing in ovarian cancer and outlines the potential pitfalls and challenges that can be encountered in HRD diagnostics. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000940431200001; volume:13; issue:2; firstpage:284; journal:JOURNAL OF PERSONALIZED MEDICINE; https://hdl.handle.net/11588/913406Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85148935398 |
| DOI: | 10.3390/jpm13020284 |
| الإتاحة: | https://doi.org/10.3390/jpm13020284Test https://hdl.handle.net/11588/913406Test |
| رقم الانضمام: | edsbas.EE38B4EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/jpm13020284 |
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