التفاصيل البيبلوغرافية
| العنوان: |
Effects of short-term reduction in serum cholesterol with simvastatin in patients with stable angina pectoris and mild to moderate hypercholesterolemia |
| المؤلفون: |
de Divitiis, M, Di Somma, S, Montefusco, S, Carreras, G, Greco, V, Carotenuto, A, de Divitiis, O., RUBBA, PAOLO OSVALDO FEDERICO, LIGUORI, VINCENZO, GALDERISI, MAURIZIO, IANNUZZO, GABRIELLA |
| المساهمون: |
de Divitiis, M, Rubba, PAOLO OSVALDO FEDERICO, Di Somma, S, Liguori, Vincenzo, Galderisi, Maurizio, Montefusco, S, Carreras, G, Greco, V, Carotenuto, A, Iannuzzo, Gabriella, de Divitiis, O. |
| سنة النشر: |
1996 |
| المجموعة: |
IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: |
Analysis of Variance, Angina Pectori, Anticholesteremic Agent, Cholesterol, LDL, Electrocardiography, Exercise Test, Forearm, Human, Hypercholesterolemia, Lovastatin, Middle Aged, Regional Blood Flow, Simvastatin, Single-Blind Method |
| الوصف: |
To evaluate the effects of short-term cholesterol-lowering treatment on myocardial effort ischemia, 22 patients with stable effort ischemia and mild to moderate hypercholesterolemia (low density lipoprotein [LDL] cholesterol 160 to 220 mg/dl) were randomly allocated at baseline (TO) in 2 groups. Group A included 12 patients treated with simvastatin 10 mg bid; group B included 10 patients treated with placebo. All patients underwent a treadmill electrocardiography (ECG) test; total cholesterol, HDL and LDL cholesterol, triglycerides, plasma, and blood viscosity were measured. All tests were repeated after 4 and 12 weeks. For 18 of the same patients (11 taking simvastatin, 7 receiving placebo), forearm strain-gouge plethysmography was performed at baseline and after 4 weeks, both at rest and during reactive hyperemia. At 4 and 12 weeks, group A showed a significant reduction in total cholesterol (p <0.05) and LDL (p <0.05), with unchanged HDL, triglycerides, blood, and plasma viscosity. Effort was unmodified, ST-segment depression at peak effort and ischemic threshold were significantly improved after 4 and 12 weeks (all p <0.05) with unchanged heart rate x systolic blood pressure product. A significant increase in the excess flow response to reactive hyperemia was detected in group A (p <0.03); group B showed no changes in hematochemical and ergometric parameters. These data suggest that cholesterol-lowering treatment is associated with an improvement in myocardial effort ischemia; this might be explained by a more pronounced increase of coronary blood flow and capacity of vasodilation in response to effort. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
volume:78; issue:7; firstpage:763-8; journal:THE AMERICAN JOURNAL OF CARDIOLOGY; http://hdl.handle.net/11588/645952Test |
| الإتاحة: |
http://hdl.handle.net/11588/645952Test |
| رقم الانضمام: |
edsbas.80277599 |
| قاعدة البيانات: |
BASE |
