دورية أكاديمية
Human RCAN3 gene expression and cell growth in endothelial cells.
| العنوان: | Human RCAN3 gene expression and cell growth in endothelial cells. |
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| المؤلفون: | CANAIDER, SILVIA, VETTRAINO, MARINA ELEONORA, SPISNI, ENZO, FACCHIN, FEDERICA, Norling LV, Cooper D, Perretti M. |
| المساهمون: | Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D, Perretti M. |
| سنة النشر: | 2010 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | regulator of calcineurin 3, proliferation, inflammation, human umbilical vein endothelial cells, vascular endothelial growth factor, phorbol 12-myristate 13-acetate |
| الوصف: | Regulator of calcineurin 3 (RCAN3) belongs to the human RCAN gene family, which also includes RCAN1 and RCAN2. All three members interact with and inhibit calci- neurin. Based on this effect, several studies have demonstrated a role for RCAN1 and RCAN2 on inflammation, using human umbilical vein endothelial cells (HUVECs) as a model. RCAN1 and 2 are strongly induced by vascular endothelial growth factor (VEGF), inhibit cell proliferation and down- regulate many pro-inflammatory and pro-angiogenic genes. The present work is the first study to investigate the role of RCAN3 on inflammation in HUVECs. RCAN3 isoforms have been characterized and quantified in HUVECs; only those with the same frame are expressed and show a peculiar expression pattern. RCAN3 inhibits HUVEC proliferation both basally and under VEGF or phorbol 12-myristate 13- acetate-stimulated conditions, however it does not modulate gene expression of the chosen inflammatory genes. Results indicate an interesting role for RCAN3 in modulating HUVEC proliferation, independently from the inflammatory and angiogenic processes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/21042787; info:eu-repo/semantics/altIdentifier/wos/WOS:000285035800019; volume:26; issue:6; firstpage:913; lastpage:918; numberofpages:6; journal:INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE; http://hdl.handle.net/11585/92356Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-78649946402 |
| DOI: | 10.3892/ijmm_00000542 |
| الإتاحة: | https://doi.org/10.3892/ijmm_00000542Test http://hdl.handle.net/11585/92356Test |
| رقم الانضمام: | edsbas.847F8535 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3892/ijmm_00000542 |
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