دورية أكاديمية
A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility
| العنوان: | A large-scale genetic analysis reveals a strong contribution of the HLA class II region to giant cell arteritis susceptibility |
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| المؤلفون: | Carmona, F. David, Mackie, Sarah L., Martín, Jose Ezequiel, Taylor, John C., Vaglio, Augusto, Eyre, Stephen, Bossini Castillo, Lara, Castañeda, Santos, Cid, Maria C., Hernández Rodríguez, José, Prieto González, Sergio, Solans, Roser, Ramentol Sintas, Marc, González Escribano, M. Francisca, Ortiz Fernández, Lourdes, Morado, Inmaculada C., Narváez, Javier, Miranda Filloy, José A., Beretta, Lorenzo, Lunardi, Claudio, Cimmino, Marco A., Gianfreda, Davide, Santilli, Daniele, Ramirez, Giuseppe A., Soriano, Alessandra, Muratore, Francesco, Pazzola, Giulia, ADDIMANDA, OLGA, Wijmenga, Cisca, Witte, Torsten, Schirmer, Jan H., Moosig, Frank, Schönau, Verena, Franke, Andre, Palm, Oyvind, Molberg, Oyvind, Diamantopoulos, Andreas P., Carette, Simon, Cuthbertson, David, Forbess, Lindsy J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., Mcalear, Carol A., Moreland, Larry, Monach, Paul A., Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg, Steven R., Gregersen, Peter K., Pease, Colin T., Gough, Andrew, Green, Michael, Hordon, Lesley, Jarrett, Stephen, Watts, Richard, Levy, Sarah, Patel, Yusuf, Kamath, Sanjeet, Dasgupta, Bhaskar, Worthington, Jane, Koeleman, Bobby P. C., De Bakker, Paul I. W., Barrett, Jennifer H., Salvarani, Carlo, Merkel, Peter A., González Gay, Miguel A., Morgan, Ann W., Martín, Javier |
| المساهمون: | Carmona, F. David, Mackie, Sarah L., Martín, Jose-Ezequiel, Taylor, John C., Vaglio, Augusto, Eyre, Stephen, Bossini-Castillo, Lara, Castañeda, Santo, Cid, Maria C., Hernández-Rodríguez, José, Prieto-González, Sergio, Solans, Roser, Ramentol-Sintas, Marc, González-Escribano, M. Francisca, Ortiz-Fernández, Lourde, Morado, Inmaculada C., Narváez, Javier, Miranda-Filloy, José A., Beretta, Lorenzo, Lunardi, Claudio, Cimmino, Marco A., Gianfreda, Davide, Santilli, Daniele, Ramirez, Giuseppe A., Soriano, Alessandra, Muratore, Francesco, Pazzola, Giulia, Addimanda, Olga, Wijmenga, Cisca, Witte, Torsten, Schirmer, Jan H., Moosig, Frank, Schönau, Verena, Franke, Andre, Palm, Oyvind, Molberg, Oyvind, Diamantopoulos, Andreas P., Carette, Simon, Cuthbertson, David, Forbess, Lindsy J., Hoffman, Gary S., Khalidi, Nader A., Koening, Curry L., Langford, Carol A., Mcalear, Carol A., Moreland, Larry, Monach, Paul A., Pagnoux, Christian, Seo, Philip, Spiera, Robert, Sreih, Antoine G., Warrington, Kenneth J., Ytterberg, Steven R., Gregersen, Peter K., Pease, Colin T., Gough, Andrew, Green, Michael, Hordon, Lesley, Jarrett, Stephen, Watts, Richard, Levy, Sarah, Patel, Yusuf, Kamath, Sanjeet, Dasgupta, Bhaskar, Worthington, Jane, Koeleman, Bobby P.C., De Bakker, Paul I.W., Barrett, Jennifer H., Salvarani, Carlo, Merkel, Peter A., González-Gay, Miguel A., Morgan, Ann W., Martín, Javier |
| سنة النشر: | 2015 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Cohort Studie, European Continental Ancestry Group, Genes, MHC Class II, Genetic Association Studie, Genotype, Giant Cell Arteriti, Human, Multifactorial Inheritance, Multivariate Analysi, Odds Ratio, Genetic, Genetics (clinical) |
| الوصف: | We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and 15,306 unrelated control subjects from six different countries of European ancestry, was genotyped by the Immunochip array. We also imputed HLA data with a previously validated imputation method to perform a more comprehensive analysis of this genomic region. The strongest association signals were observed in the HLA region, with rs477515 representing the highest peak (p = 4.05 × 10-40, OR = 1.73). A multivariate model including class II amino acids of HLA-DRβ1 and HLA-DQα1 and one class I amino acid of HLA-B explained most of the HLA association with GCA, consistent with previously reported associations of classical HLA alleles like HLA-DRB1∗04. An omnibus test on polymorphic amino acid positions highlighted DRβ1 13 (p = 4.08 × 10-43) and HLA-DQα1 47 (p = 4.02 × 10-46), 56, and 76 (both p = 1.84 × 10-45) as relevant positions for disease susceptibility. Outside the HLA region, the most significant loci included PTPN22 (rs2476601, p = 1.73 × 10-6, OR = 1.38), LRRC32 (rs10160518, p = 4.39 × 10-6, OR = 1.20), and REL (rs115674477, p = 1.10 × 10-5, OR = 1.63). Our study provides evidence of a strong contribution of HLA class I and II molecules to susceptibility to GCA. In the non-HLA region, we confirmed a key role for the functional PTPN22 rs2476601 variant and proposed other putative risk loci for GCA involved in Th1, Th17, and Treg cell function. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/25817017; info:eu-repo/semantics/altIdentifier/wos/WOS:000352212600005; volume:96; issue:4; firstpage:565; lastpage:580; numberofpages:16; journal:AMERICAN JOURNAL OF HUMAN GENETICS; http://hdl.handle.net/11585/590949Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84926262586; http://www.elsevier.com/wps/find/journaldescription.cws_home/713561/description#descriptionTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385191Test/ |
| DOI: | 10.1016/j.ajhg.2015.02.009 |
| الإتاحة: | https://doi.org/10.1016/j.ajhg.2015.02.009Test http://hdl.handle.net/11585/590949Test http://www.elsevier.com/wps/find/journaldescription.cws_home/713561/description#descriptionTest https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385191Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F2BB1941 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ajhg.2015.02.009 |
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