دورية أكاديمية
Which serum uric acid levels are associated with increased cardiovascular risk in the general adult population?
| العنوان: | Which serum uric acid levels are associated with increased cardiovascular risk in the general adult population? |
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| المؤلفون: | Krajčoviechová A, Wohlfahrt P, Bruthans J, Šulc P, Lánská V, Eremiášová L, Pudil J, Linhart A, Filipovský J, Mayer O, Widimský J, Blaha M, Borghi C, Cífková R. |
| المساهمون: | Krajčoviechová A, Wohlfahrt P, Bruthans J, Šulc P, Lánská V, Eremiášová L, Pudil J, Linhart A, Filipovský J, Mayer O, Widimský J, Blaha M, Borghi C, Cífková R. |
| سنة النشر: | 2020 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | SCORE, cardiovascular, gender difference, risk, uric acid |
| الوصف: | Our aim was to determine the serum uric acid (SUA) levels associated with an increased risk of cardiovascular (CV) and all-cause death in the general adult population. We analyzed data obtained in two independent cross-sectional surveys performed in the Czech Republic in 2006-09 and 2015-18, involving 1% population random samples in nine districts, aged 25-64 years, stratified by age and gender. Ten-year mortality data were obtained in a cohort with examination in 2006-09. Final analyses included 3542 individuals (48.2% men) examined in 2006-09, and 2304 (47.4% men) examined in 2015-18. From a cohort examined in 2006-09, 122 men and 60 women were reported dead (33% and 27% from CV disease). In men, there was no association of baseline SUA levels with baseline SCORE category or 10-year mortality rates. In women, each 10 μmol/L increase in baseline SUA levels was associated with an increase in baseline SCORE category (P < .001). Receiver operating characteristic curve analyses in women identified the baseline SUA cutoff values discriminating: 1. between low/intermediate and high/very high SCORE categories (309 μmol/L), 2. CV mortality (325 μmol/L), and 3. all-cause mortality (298 μmol/L). After adjusting for confounders including SCORE, Cox regression analysis confirmed that the baseline SUA cutoffs of 309 μmol/L and 325 μmol/L were associated with 4-times (P = .010) and 6-times (P = .036) greater risk of CV mortality, whereas the cutoff of 298 μmol/L was associated with 87% greater risk of all-cause mortality (P = .025). In conclusion, the SUA cutoff value of 309 μmol/L identified women at high/very high SCORE category and was associated with 4-times greater risk of observed CV mortality over 10 years. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32271996; info:eu-repo/semantics/altIdentifier/wos/WOS:000534198500015; volume:22; issue:5; firstpage:897; lastpage:905; numberofpages:9; journal:THE JOURNAL OF CLINICAL HYPERTENSION; http://hdl.handle.net/11585/762510Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85083069299 |
| DOI: | 10.1111/jch.13847 |
| الإتاحة: | https://doi.org/10.1111/jch.13847Test http://hdl.handle.net/11585/762510Test |
| رقم الانضمام: | edsbas.9A9B5295 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jch.13847 |
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