دورية أكاديمية
Onset of narcolepsy type 1 in a paraneoplastic encephalitis associated with a thymic seminoma
| العنوان: | Onset of narcolepsy type 1 in a paraneoplastic encephalitis associated with a thymic seminoma |
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| المؤلفون: | Rossi S., Asioli G. M., Rizzo G., Sallemi G., Moresco M., Franceschini C., Pizza F., Plazzi G. |
| المساهمون: | Rossi S., Asioli G.M., Rizzo G., Sallemi G., Moresco M., Franceschini C., Pizza F., Plazzi G. |
| سنة النشر: | 2021 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | genetic, HLA*DQB1, hypocretin, Ma2, onconeural, orexin, Adult, Human, Intracellular Signaling Peptides and Protein, Male, Young Adult, Encephaliti, Narcolepsy, Neuropeptide, Seminoma, Testicular Neoplasms |
| الوصف: | Narcolepsy type 1 results from probable autoimmune disruption of hypothalamic hypocretinergic neurons. Secondary narcolepsy can occur as a result of other conditions affecting the central nervous system, including limbic paraneoplastic encephalitis. We report the case of a 19-year-old patient presenting with acute-onset diurnal hypersomnolence, hyperphagia, sexual dysfunction, and psychiatric disturbances. Further investigations revealed a limbic paraneoplastic encephalitis associated with mediastinal thymic seminoma. Tumor removal and immunosuppressive treatment resulted in a partial benefit on psychiatric disturbances but did not improve daytime sleepiness. A comprehensive sleep assessment led to the diagnosis of secondary narcolepsy type 1 with reduced cerebrospinal fluid hypocretin-1 levels and revealed the presence of the HLA DQB1*0602 allele, typically associated with idiopathic narcolepsy, for which we hypothesize a possible immunopathogenic role. Sodium oxybate was successfully administered. Narcolepsy is often overlooked in patients with limbic paraneoplastic encephalitis. A prompt assessment and an adequate symptomatic treatment can improve the disease burden. CITATION: Rossi S, Asioli GM, Rizzo G, etal. Onset of narcolepsy type 1 in a paraneoplastic encephalitis associated with a thymic seminoma. J Clin Sleep Med. 2021;17(12):2557-2560. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34170236; info:eu-repo/semantics/altIdentifier/wos/WOS:000735728800023; volume:17; issue:12; firstpage:2557; lastpage:2560; numberofpages:4; journal:JOURNAL OF CLINICAL SLEEP MEDICINE; http://hdl.handle.net/11585/859835Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85122489887 |
| DOI: | 10.5664/jcsm.9496 |
| الإتاحة: | https://doi.org/10.5664/jcsm.9496Test http://hdl.handle.net/11585/859835Test |
| رقم الانضمام: | edsbas.B1E818CF |
| قاعدة البيانات: | BASE |
| DOI: | 10.5664/jcsm.9496 |
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