دورية أكاديمية
MGMT promoter methylation status in clival chordoma
| العنوان: | MGMT promoter methylation status in clival chordoma |
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| المؤلفون: | MARUCCI, GIANLUCA, MORANDI, LUCA, MAZZATENTA, DIEGO, FRANK, GIORGIO, PASQUINI, ERNESTO, FOSCHINI, MARIA PIA |
| المساهمون: | Marucci, Gianluca, Morandi, Luca, Mazzatenta, Diego, Frank, Giorgio, Pasquini, Ernesto, Foschini, Maria Pia |
| سنة النشر: | 2014 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Chordoma, Clivu, Methylation, MGMT, Temozolomide, Adult, Aged, DNA Modification Methylase, DNA Mutational Analysi, DNA Repair Enzyme, Female, Follow-Up Studie, Human, Immunohistochemistry, Isocitrate Dehydrogenase, Male, Middle Aged, Neoplasm Recurrence, Local, Skull Base Neoplasm, Tumor Suppressor Protein, Cranial Fossa, Posterior, DNA Methylation, Promoter Regions, Genetic, Neurology (clinical), Cancer Research, Oncology, Neurology |
| الوصف: | Chordomas are rare, slow-growing neoplasms, characterized by locally aggressive growth patterns and high local recurrence rates. To the best of our knowledge, the MGMT promoter methylation status has not been studied in a population of patients with chordomas to determine if a biologic rationale exists to support the use of temozolomide. We here show for the first time that methylation of MGMT promoter is present in a significant portion or recurring clival chordomas; on the contrary in clival chordomas without recurrence MGMT promoter was always unmethylated (p = 0.0317). Although these observations need to be confirmed in a larger study population, our results (1) indicate that methylation of MGMT promoter is present in a significant portion of recurring chordomas, and (2) prompt further investigation into the potential role of temozolomide as an adjuvant treatment of these tumors. © 2014 Springer Science+Business Media New York. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/24771251; info:eu-repo/semantics/altIdentifier/wos/WOS:000337024300006; volume:118; issue:2; firstpage:271; lastpage:276; numberofpages:6; journal:JOURNAL OF NEURO-ONCOLOGY; http://hdl.handle.net/11585/566605Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84903887634; www.wkap.nl/journalhome.htm/0167-594X |
| DOI: | 10.1007/s11060-014-1445-y |
| الإتاحة: | https://doi.org/10.1007/s11060-014-1445-yTest http://hdl.handle.net/11585/566605Test |
| رقم الانضمام: | edsbas.33061F5E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11060-014-1445-y |
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