دورية أكاديمية
Novel markers in pediatric-type follicular lymphoma
| العنوان: | Novel markers in pediatric-type follicular lymphoma |
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| المؤلفون: | Agostinelli C., Akarca A. U., Ramsay A., Rizvi H., Rodriguez-Justo M., Pomplun S., Proctor I., Sabattini E., Linch D., Daw S., Pittaluga S., Pileri S. A., Jaffe E. S., Quintanilla-Martinez L., Marafioti T. |
| المساهمون: | Agostinelli C., Akarca A.U., Ramsay A., Rizvi H., Rodriguez-Justo M., Pomplun S., Proctor I., Sabattini E., Linch D., Daw S., Pittaluga S., Pileri S.A., Jaffe E.S., Quintanilla-Martinez L., Marafioti T. |
| سنة النشر: | 2019 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Differential diagnosi, FOXP-1, Immunohistochemistry, Pediatric-type follicular lymphoma, Adolescent, Adult, Child, Diagnosis, Differential, Forkhead Transcription Factor, Human, Immunophenotyping, Lymphoma, B-Cell, Follicular, Male, Repressor Protein, Stathmin, Young Adult |
| الوصف: | The aim of this study was to review the histopathological, phenotypic, and molecular characteristics of pediatric-type follicular lymphoma (PTFL) and to assess the diagnostic value of novel immunohistochemical markers in distinguishing PTFL from follicular hyperplasia (FH). A total of 13 nodal PTFLs were investigated using immunohistochemistry, fluorescence in situ hybridization (FISH), and PCR and were compared with a further 20 reactive lymph nodes showing FH. Morphologically, PTFL cases exhibited a follicular growth pattern with irregular lymphoid follicles in which the germinal centers were composed of numerous blastoid cells showing a starry-sky appearance. Immunohistochemistry highlighted preserved CD10 (13/13) and BCL6 (13/13) staining, CD20 (13/13) positivity, a K light chain predominance (7/13), and partial BCL2 expression in 6/13 cases (using antibodies 124, E17, and SP66). The germinal center (GC)–associated markers stathmin and LLT-1 were positive in most of the cases (12/13 and 12/13, respectively). Interestingly, FOXP-1 was uniformly positive in PTFL (12/13 cases) in contrast to reactive GCs in FH, where only a few isolated positive cells were observed. FISH revealed no evidence of BCL2, BCL6, or MYC rearrangements in the examined cases. By PCR, clonal immunoglobulin gene rearrangements were detected in 100% of the tested PTFL cases. Our study confirmed the unique morphological and immunophenotypic features of PTFL and suggests that FOXP-1 can represent a novel useful diagnostic marker in the differential diagnosis between PTFL and FH. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31686194; info:eu-repo/semantics/altIdentifier/wos/WOS:000494004300002; volume:475; issue:6; firstpage:771; lastpage:779; numberofpages:9; journal:VIRCHOWS ARCHIV; http://hdl.handle.net/11585/725148Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85074802526; link.springer.de/link/service/journals/00428/index.htm |
| DOI: | 10.1007/s00428-019-02681-y |
| الإتاحة: | https://doi.org/10.1007/s00428-019-02681-yTest http://hdl.handle.net/11585/725148Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.86691847 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00428-019-02681-y |
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