دورية أكاديمية
Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride–exposed worker
| العنوان: | Sequential development of hepatocellular carcinoma and liver angiosarcoma in a vinyl chloride–exposed worker |
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| المؤلفون: | Guido, Maria, Sarcognato, Samantha, Pelletti, Guido, Fassan, Matteo, Murer, Bruno, Snenghi, Rossella |
| المساهمون: | Guido, Maria*, Sarcognato, Samantha, Pelletti, Guido, Fassan, Matteo, Murer, Bruno, Snenghi, Rossella |
| سنة النشر: | 2016 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Hepatocellular carcinoma, Immunohistochemistry, Liver angiosarcoma, Liver toxicity, Micronucleu, Vinyl chloride, Aged, Antigens, CD34, Biomarkers, Tumor, Biopsy, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, DNA Mutational Analysi, Hemangiosarcoma, Hepatectomy, Human, Liver, Liver Neoplasm, Male, Micronuclei, Chromosome-Defective, Occupational Disease, Occupational Exposure, Point Mutation, Proto-Oncogene Proteins p21(ras) |
| الوقت: | 2734 |
| الوصف: | Strong experimental and clinical evidences have definitely linked occupational vinyl chloride exposure to development of angiosarcoma of the liver. In contrast, despite the International Agency for Research on Cancer having included vinyl chloride among the causes of hepatocellular carcinoma, the association between vinyl chloride exposure and hepatocellular carcinoma remains debated. This issue is relevant, because occupational exposure to high levels of vinyl chloride may still occur. We report a unique case of sequential occurrences of hepatocellular carcinoma and angiosarcoma of the liver, in a vinyl chloride–exposed worker without cirrhosis and any known risk factor for chronic liver disease. Both the hepatocellular carcinoma and the surrounding normal liver showed micronucleus formation, which reflects genotoxic effect of vinyl chloride. Angiosarcoma showed a KRAS G12D point mutation, which is considered to be characteristic of vinyl chloride–induced angiosarcoma. This case supports the pathogenic role of vinyl chloride in both hepatocellular carcinoma and angiosarcoma development. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27544804; info:eu-repo/semantics/altIdentifier/wos/WOS:000386644600026; volume:57; firstpage:193; lastpage:196; numberofpages:4; journal:HUMAN PATHOLOGY; http://hdl.handle.net/11585/627940Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84988000703; http://www.elsevier.com/inca/publications/store/6/2/3/1/3/9/index.httTest |
| DOI: | 10.1016/j.humpath.2016.07.021 |
| الإتاحة: | https://doi.org/10.1016/j.humpath.2016.07.021Test http://hdl.handle.net/11585/627940Test http://www.elsevier.com/inca/publications/store/6/2/3/1/3/9/index.httTest |
| رقم الانضمام: | edsbas.E7F4DAE3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.humpath.2016.07.021 |
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