دورية أكاديمية
Intrafollicular Epstein-Barr virus-positive large B cell lymphoma. A variant of “germinotropic” lymphoproliferative disorder
| العنوان: | Intrafollicular Epstein-Barr virus-positive large B cell lymphoma. A variant of “germinotropic” lymphoproliferative disorder |
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| المؤلفون: | Lorenzi, Luisa, Lonardi, Silvia, Essatari, Murad H. M., Pellegrini, Vilma, Fisogni, Simona, Vermi, William, Rossi, Giuseppe, Massarelli, Giovannino, Facchetti, Fabio, GAZZOLA, ANNA, AGOSTINELLI, CLAUDIO, PILERI, STEFANO |
| المساهمون: | Lorenzi, Luisa, Lonardi, Silvia, Essatari, Murad H. M., Pellegrini, Vilma, Fisogni, Simona, Gazzola, Anna, Agostinelli, Claudio, Vermi, William, Rossi, Giuseppe, Massarelli, Giovannino, Pileri, Stefano A., Facchetti, Fabio |
| سنة النشر: | 2016 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | B cell lymphoma, Epstein-Barr viru, Germinotropic, Aged, Epstein-Barr Virus Infection, Female, Germinal Center, Human, Immunohistochemistry, Immunophenotyping, In Situ Hybridization, Fluorescence, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Phenotype, Polymerase Chain Reaction, Molecular Biology, Cell Biology |
| الوقت: | 2734 |
| الوصف: | Germinotropic lymphoproliferative disorders were previously described as localized disorders associated with coinfection by human herpes virus 8 and Epstein-Barr virus and characterized by good clinical outcome. We report the clinical, morphological, phenotypical, and molecular features of three cases of a hitherto unreported variant of Epstein-Barr virus (EBV)-positive, human herpes virus 8 (HHV8)-negative large B cell lymphoma with exclusive intrafollicular localization. All cases occurred in elderly individuals (63, 77, and 65 years old; one male, two females) without obvious immunedeficiency, who presented with high stage disease. Lymph nodes showed an effaced nodular architecture with abnormal B follicles colonized by EBV+ large, pleomorphic atypical cells, including Reed-Sternberg-like cells, showing an activated B cell phenotype (CD10-FOXP1-Bcl6-IRF4+ or CD10-FOXP1+Bcl6+IRF4+) and intense expression of CD30. No monoclonal light-chain restriction was detected by immunohistochemistry or in situ hybridization, and IGH rearrangement was polyclonal; notably, EBV clonality was detectable in one case. Lymphoma cells in all cases showed diffuse expression of the c-Myc protein, while Bcl2 was dim or negative; moreover, the strong expression of phosphorylated-STAT3 in tumor cell nuclei suggested activation of the JAK-STAT pathway. FISH analysis was performed in two cases and showed no translocations of BCL2, BCL6, MYC, and PAX5 genes. Response to treatment was poor in 2/3 patients: one died after 18 months, one is alive with disease after 12 months. The intrafollicular EBV-positive large B cell lymphoma expands the spectrum of EBV-associated lymphoproliferative disorders in immunocompetent individuals. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26762526; info:eu-repo/semantics/altIdentifier/wos/WOS:000374312900008; volume:468; issue:4; firstpage:441; lastpage:450; numberofpages:10; journal:VIRCHOWS ARCHIV; http://hdl.handle.net/11585/580383Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84954307299; link.springer.de/link/service/journals/00428/index.htm |
| DOI: | 10.1007/s00428-015-1902-9 |
| الإتاحة: | https://doi.org/10.1007/s00428-015-1902-9Test http://hdl.handle.net/11585/580383Test |
| رقم الانضمام: | edsbas.8E2C1335 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00428-015-1902-9 |
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