دورية أكاديمية
Pharmacogenomic influence on sepsis outcome in critically ill patients
| العنوان: | Pharmacogenomic influence on sepsis outcome in critically ill patients |
|---|---|
| المؤلفون: | Allegra, S., Fatiguso, G., Baietto, L., Corcione, S., Favata, F., Ariaudo, A., Pagani, N., Ranieri, V. M., De Rosa, F. G., Di Perri, G., D’Avolio, A. |
| المساهمون: | Allegra, S., Fatiguso, G., Baietto, L., Corcione, S., Favata, F., Ariaudo, A., Pagani, N., Ranieri, V.M., De Rosa, F.G., Di Perri, G., D’Avolio, A. |
| سنة النشر: | 2017 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | creatinine, linezolid, multidrug resistance associated protein 2, multidrug resistance associated protein 4, multidrug resistance protein 1, antiinfective agent, adult, aged, Article, clinical article, critically ill patient, cystic fibrosi, diabetes mellitu, endocarditi, female, human, intensive care unit, male, middle aged, outcome assessment, pharmacogenomic, polymerase chain reaction, sepsi, single nucleotide polymorphism, young adult, allele, bacteremia, critical illne, genetic, Italy |
| الوصف: | In infectious and inflammatory diseases, pharmacogenetics affects treatment efficacy and toxicity. Moreover, recent studies suggest its important role in predicting the clinical outcome of sepsis. Our aim was to investigate the influence of single nucleotide polymorphisms (SNPs) in genes which we supposed to be involved in linezolid elimination upon sepsis outcome. Fourteen ICU-admitted patients in therapy with intravenous linezolid (600 mg q12 h) were enrolled and classified into three groups: group 0 for sepsis, 1 for severe sepsis and 2 for septic shock. Genotyping for SNPs in MDR1 3435 rs1045642 C>T, 2677 rs2032582 G>T and 1236 rs1128503 C>T, MRP2 -24 rs717620 G>A and 1249 rs2273697 G>A, MRP4 *879 rs1059751 T>C and 3348 rs1751034 T>C, BCRP1 421 rs2231142 C>A and 1194+928 rs13120400 T>C, -127 rs4149170 G>A and OCT1 480 rs683369 C>G genes was done using real-time PCR allelic discrimination assay. The Mann-Whitney statistical test was used to analyse variables. MDR1 2677 (p=0.012), MRP2 1249 (p=0.038), MRP4 *879 (p=0.032) and 3348 SNPs significantly influenced the sepsis score. Our study, despite its limited sample size, could be decisive for early sepsis prediction and may improve the management of critically ill patients. © 2017, EDIMES Edizioni Medico Scientifiche. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | volume:25; issue:1; firstpage:45; lastpage:49; numberofpages:5; journal:LE INFEZIONI IN MEDICINA; http://hdl.handle.net/11585/663696Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85017016824; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017016824&partnerID=40&md5=c0de44002469c9f93e6bc082c53d79abTest |
| الإتاحة: | http://hdl.handle.net/11585/663696Test https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017016824&partnerID=40&md5=c0de44002469c9f93e6bc082c53d79abTest |
| رقم الانضمام: | edsbas.CA877731 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |