دورية أكاديمية
Association between Sirtuin 1 Gene rs10997870 polymorphism and suicide behaviors in bipolar disorder
| العنوان: | Association between Sirtuin 1 Gene rs10997870 polymorphism and suicide behaviors in bipolar disorder |
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| المؤلفون: | Nivoli, Alessandra, Albani, Diego, Forloni, Gianluigi, Fusco, Federica, Colom, Francesc, Vieta, Eduard, PORCELLI, STEFANO LUIGI, SERRETTI, ALESSANDRO |
| المساهمون: | Nivoli, Alessandra, Porcelli, Stefano, Albani, Diego, Forloni, Gianluigi, Fusco, Federica, Colom, Francesc, Vieta, Eduard, Serretti, Alessandro |
| سنة النشر: | 2016 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | Bipolar disorder, rs10997870 polymorphism, SIRT1 gene variant, Suicidal behavior, Adult, Allele, Cohort Studie, Depression, Female, Genotype, Human, Logistic Model, Male, Middle Aged, Multivariate Analysi, Polymorphism, Genetic, Psychomotor Agitation, Sirtuin 1, Suicidal Ideation, Suicide, Attempted, Neuropsychology and Physiological Psychology, Psychiatry and Mental Health, Biological Psychiatry |
| الوصف: | Background/Aims: Suicidal behavior (SB) in bipolar disorder (BD) is a complex multifactorial event resulting from an interaction of genetic, neurobiological and psychosocial factors. Recent studies identified new possible mechanisms, suggesting a role for sirtuins (SIRTs 1-7), a family of nicotinamide adenine dinucleotide-dependent enzymes with a multifaceted role in the central nervous system. The aims of the present study were: (1) to investigate the effects of the rs10997870 SIRT1 gene variant on SB in BD; (2) to explore the effects of the same gene variant on specific depressive symptoms at the severest episode. Methods: One hundred and eighty DSM-IV bipolar outpatients were enrolled in a naturalistic cohort study. The rs10997870 polymorphism within the SIRT1 gene was analyzed. Results: An association between the GG genotype and SB was detected (lifetime: p = 0.015). Compared to other genotypes, GG carriers presented more frequently psychomotor agitation (p = 0.009) and a higher Hamilton Depression Rating Scale total score (p = 0.014) at the severest depressive episode. SB and psychomotor agitation were found to be associated with GG carriers and G allele in a multivariate analysis as well. Conclusion: Our findings suggest a role of the rs10997870 SIRT1 gene variant in SB amongst BD patients and its association with specific depressive symptoms. Despite a number of limitations of this exploratory study, our results may provide new insight into the mechanisms underlying SB in BD. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27424200; info:eu-repo/semantics/altIdentifier/wos/WOS:000390548400001; volume:74; issue:1; firstpage:1; lastpage:7; numberofpages:7; journal:NEUROPSYCHOBIOLOGY; http://hdl.handle.net/11585/585582Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84978933093; www.karger.com/journals/nps/nps_jh.htm |
| DOI: | 10.1159/000446921 |
| الإتاحة: | https://doi.org/10.1159/000446921Test http://hdl.handle.net/11585/585582Test |
| رقم الانضمام: | edsbas.CA78AF23 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000446921 |
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